TY - JOUR
T1 - Nampt
T2 - linking NAD biology, metabolism and cancer
AU - Garten, Antje
AU - Petzold, Stefanie
AU - Körner, Antje
AU - Imai, Shin ichiro
AU - Kiess, Wieland
N1 - Funding Information:
We thank all the colleagues who contributed to this work and apologize to the authors whose works on Nampt/PBEF/visfatin were not directly discussed because of the focus of this review and space limitations. We also thank Anja Barnikol-Oettler, Antje Berthold and Roy Tauscher for expert technical assistance. Our studies are supported by a grant from the German Research Council (Deutsche Forschungsgemeinschaft) KFO 152: ‘Atherobesity’, TP 1 and 5 (to A.K. and W.K.) and unrestricted grants by Merck Serono, Ipsen and Novo Nordisk (to W.K.). S.I. is supported by grants from NIA (AG024150), American Diabetes Association, Juvenile Diabetes Research Foundation, the Glenn Award for Research in Biological Mechanisms of Aging, the Ellison Medical Foundation and the Longer Life Foundation.
PY - 2009/4
Y1 - 2009/4
N2 - Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD) intermediate. Previously identified as a cytokine pre-B-cell colony-enhancing factor and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in several fields, including NAD biology, metabolism and inflammation. As a NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and influences a variety of metabolic and stress responses. Nampt also plays an important part in regulating insulin secretion in pancreatic β-cells. Nampt seems to have another function as an immunomodulatory cytokine and, therefore, has a role in inflammation. This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer.
AB - Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD) intermediate. Previously identified as a cytokine pre-B-cell colony-enhancing factor and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in several fields, including NAD biology, metabolism and inflammation. As a NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and influences a variety of metabolic and stress responses. Nampt also plays an important part in regulating insulin secretion in pancreatic β-cells. Nampt seems to have another function as an immunomodulatory cytokine and, therefore, has a role in inflammation. This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer.
UR - http://www.scopus.com/inward/record.url?scp=62649156291&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2008.10.004
DO - 10.1016/j.tem.2008.10.004
M3 - Review article
C2 - 19109034
AN - SCOPUS:62649156291
SN - 1043-2760
VL - 20
SP - 130
EP - 138
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 3
ER -