Nab-paclitaxel in older patients with non–small cell lung cancer who have developed disease progression after platinum-based doublet chemotherapy

Jared M. Weiss, Nathan Pennell, Allison M. Deal, Daniel Morgensztern, Daniel S. Bradford, Jeffrey Crane, Howard Jack West, Carrie Lee, Chad Pecot, James P. Stevenson, William Irvin, Mark Socinski, Tom Stinchcombe, Liza C. Villaruz, Hyman B. Muss

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: The selection of later-line treatment for older patients with AJCC (version 7) stage IV non–small cell lung cancer (NSCLC) remains controversial. Nanoparticle albumin–bound (nab)-paclitaxel is approved with carboplatin for the first-line treatment of patients with NSCLC and subgroup analysis of phase 3 data has suggested superior survival in older patients. Methods: The authors conducted a phase 2 study of nab-paclitaxel in 42 patients aged ≥70 years who had been treated previously with a platinum doublet regimen; patients also could have received a PD-1 inhibitor. The primary endpoint of the current study was grade 3 to 5 toxicity (according to the National Cancer Institute Common Terminology Criteria for Adverse Events [version 4.0]). In addition to response rate, progression-free survival (PFS), and overall survival (OS), geriatric assessments also were performed before and during treatment, associations between baseline sarcopenia and outcomes were explored, and changes in T lymphocyte p16 before and during treatment were measured. The authors also performed a retrospective subgroup analysis of 19 older patients who were treated with nab-paclitaxel as part of a larger, randomized, phase 2 study; data were not combined. Results: The rate of grade 3 to 5 toxicities was 33.7%. The most common grade 3 to 5 toxicities were decreased white blood cell count (11.9%), neutropenia (9.5%), and fatigue (11.9%). The response rate was 34.2% (2.6% complete response rate and 31.6% partial response rate). The median PFS was 5.2 months and the median OS was 9.3 months. Adverse prognostic factors were common: 42% of patients were frail and 39% of patients were prefrail, whereas 21% had an Eastern Cooperative Oncology Group performance status of 2 and 27% were sarcopenic. Only frailty was found to be predictive of inferior survival. A subgroup analysis of 19 older patients treated with nab-paclitaxel alone in a prior trial demonstrated a response rate of 15.8%, a PFS of 4.2 months, and an OS of 13.6 months. Conclusions: Fit and prefrail older patients with stage IV NSCLC should be considered for treatment with nab-paclitaxel after disease progression with doublet chemotherapy.

Original languageEnglish
Pages (from-to)1060-1067
Number of pages8
JournalCancer
Volume126
Issue number5
DOIs
StatePublished - Mar 1 2020

Keywords

  • elderly
  • geriatric assessment
  • lymphocyte p16
  • nanoparticle albumin–bound (nab)-paclitaxel
  • non–small cell lung cancer (NSCLC)
  • sarcopenia

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