N lines in a myopathy with myosin loss

Glenn Lopate, Alan Pestronk, Woon Chee Yee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


N lines can be seen by electron microscopy within the I band of skeletal muscle, but are poorly visualized in conventional preparations. We present a case of acute quadriplegic myopathy with myosin loss and prominent N lines. The only other reported cases of N lines were also seen in patients with myosin loss from diverse etiologies. Myosin loss and the subsequent detachment of titin from myosin may result in the formation of prominent N lines.

Original languageEnglish
Pages (from-to)1216-1219
Number of pages4
JournalMuscle and Nerve
Issue number9
StatePublished - Sep 1 1998


  • Myopathy
  • Myosin loss
  • N line
  • Titin

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