Myosin Transport and Neuronal Function

P. C. Bridgman, M. Ahmed

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Myosin-dependent transport in neurons contributes to growth and plasticity. Polarized delivery or retrieval of components (including synthetic machinery) from actin-rich cytoplasmic domains that include but are not limited to dendritic spines and presynaptic terminals is partially myosin dependent. Myosins also directly participate in receptor or vesicle recycling in these compartments through transport functions associated with both exocytosis and endocytosis. Transport between dendrites or axons and spines or presynaptic terminals requires switching between microtubule and actin filament tracks and also the engagement of different motor proteins. However, recycling within these compartments is independent of microtubules and depends only on myosin transport.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages1187-1193
Number of pages7
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Actin
  • Axon
  • Dendrite
  • Development
  • Microtubules
  • Motor proteins
  • Myosin
  • Neuron
  • Receptors
  • Recycling
  • Synapse
  • Transport

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  • Cite this

    Bridgman, P. C., & Ahmed, M. (2009). Myosin Transport and Neuronal Function. In Encyclopedia of Neuroscience (pp. 1187-1193). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00709-9