Myosin motor proteins in the cell biology of axons and other neuronal compartments

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations

Abstract

Most neurons of both the central and peripheral nervous systems express multiple members of the myosin superfamily that include nonmuscle myosin II, and a number of classes of unconventional myosins. Several classes of unconventional myosins found in neurons have been shown to play important roles in transport processes. A general picture of the myosin-dependent transport processes in neurons is beginning to emerge, although much more work still needs to be done to fully define these roles and establish the importance of myosin for axonal transport. Myosins appear to contribute to three types of transport processes in neurons; recycling of receptors or other membrane components, dynamic tethering of vesicular components, and transport or tethering of protein translational machinery including mRNA. Defects in one or more of these functions have potential to contribute to disease processes.

Original languageEnglish
Title of host publicationCell Biology of the Axon
EditorsEdward Koenig
Pages91-105
Number of pages15
DOIs
StatePublished - Sep 18 2009

Publication series

NameResults and Problems in Cell Differentiation
Volume48
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

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    Bridgman, P. C. (2009). Myosin motor proteins in the cell biology of axons and other neuronal compartments. In E. Koenig (Ed.), Cell Biology of the Axon (pp. 91-105). (Results and Problems in Cell Differentiation; Vol. 48). https://doi.org/10.1007/400_2009_10