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Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks
Melanie Meister-Broekema
, Rebecca Freilich
, Chandhuru Jagadeesan
, Jennifer N. Rauch
, Rocio Bengoechea
, William W. Motley
, E. F.Elsiena Kuiper
, Melania Minoia
, Gabriel V. Furtado
, Maria A.W.H. van Waarde
, Shawn J. Bird
, Adriana Rebelo
, Stephan Zuchner
, Peter Pytel
, Steven S. Scherer
, Federica F. Morelli
, Serena Carra
,
Conrad C. Weihl
, Steven Bergink
, Jason E. Gestwicki
Harm H. Kampinga
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Center of Regenerative Medicine
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Institute of Clinical and Translational Sciences (ICTS)
Section of Neuromuscular Medicine
Department of Neurology
DBBS - Molecular Cell Biology
DBBS - Neurosciences
Hope Center for Neurological Disorders
Research output
:
Contribution to journal
›
Article
›
peer-review
66
Scopus citations
Overview
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Keyphrases
Protein Aggregation
100%
Heat Shock Protein 70 (HSP70)
100%
Myopathy
100%
Stall
100%
Valine
25%
Chaperone
25%
Proline
25%
Leucine
25%
Gain-of-function
25%
BAG Domain
25%
Skeletal muscle Tissue
12%
Small Heat Shock Protein (sHSP)
12%
Interactome
12%
Cardiac Tissue
12%
Disease Phenotype
12%
Stress Proteins
12%
Redundant mutants
12%
Multi-domain
12%
Achilles Heel
12%
Biochemistry, Genetics and Molecular Biology
Protein Aggregation
100%
Hsp70
100%
BAG3
100%
Proline
28%
Isoleucine
28%
Valine
28%
Genetics
14%
Heat Shock Protein
14%
Interactome
14%