Myocardial potassium channels: Electrophysiological and molecular diversity

Dianne M. Barry, Jeanne M. Nerbonne

Research output: Contribution to journalReview article

199 Scopus citations

Abstract

Myocardial K+ currents function to control resting membrane potentials, the heights and durations of action potentials, and refractoriness and automaticity. They are important targets for the actions of transmitters and hormones or drugs known, or postulated, to modulate cardiac functioning. A variety of K+ currents that subserve these functions have now been identified in myocardial cells isolated from different species, as well as in cells isolated from different regions of the heart in the same species. These currents include the voltage-gated K+ types, such as the transient outward (I(to)) and delayed rectifier (I(K)) currents, as well as the inwardly rectifying currents, I(K1), I(K(ACh)), and I(K(ATP)). The physiological and functional properties of the various K+ currents/channels expressed in different myocardial cell types are the focus of this review. Advances made in cloning K+ channel subunits of the Kv, eag, Kir, and I(sK) families are discussed, and progress made in identifying the K+ channel subunits expressed in the mammalian myocardium is summarized. The relationships between the various cloned K+ channel subunits and the functional K+ channels characterized electrophysiologically in myocardial cells are explored.

Original languageEnglish
Pages (from-to)363-394
Number of pages32
JournalAnnual Review of Physiology
Volume58
DOIs
StatePublished - Jan 1 1996

Keywords

  • K channels
  • atria and ventricles
  • inward rectifiers
  • molecular cloning of ion channels
  • outward rectifiers

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