Myocardial infarct quantification in the dog by single photon emission computed tomography

J. W. Keyes, P. F. Leonard, S. L. Brody, D. J. Svetkoff, W. L. Rogers, B. R. Lucchesi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Radionuclide techniques for sizing acute myocardial infarction have been hampered by the intrinsic limitations of the scintillation camera. Emission computed tomography can overcome these limitations. Single photon emission computed tomograms of the distribution of technetium-99m pyrophosphate in acute anterior and posterior infarcts were obtained in 16 dogs after death. Tomograms were also obtained in 10 dogs during life without gating. The size of the infarcts was determined by staining gross sections of the heart with nitro blue tetrazolium, dissecting out the infarcted tissue and weighing it. Infarcts sizes were determined from the tomographic images and compared with the increased infarct sizes. Good images showing the location and three-dimensional extent of the infacrts were obtained in all dogs. The measured and calculated infarct sizes correlated well (r = 0.85). Comparison of the calculated sizes in the living (non-gated) and dead ('physiologically' gated) animals showed reasonable agreement (r = 0.87). Single photon emission computed tomography is a feasible and useful technique for localizing and sizing acute myocardial infarctions

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalUnknown Journal
Issue number2
StatePublished - 1978


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