Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy

Ari J. Wassner; Rebecca H. Jugo; David M. Dorfman; Robert F. Padera; Michelle A. Maynard; Ann M. Zavacki; Patrick Y. Jay; Stephen A. Huang

doi:10.1089/thy.2016.0570

Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy

Ari J. Wassner, Rebecca H. Jugo, David M. Dorfman, Robert F. Padera, Michelle A. Maynard, Ann M. Zavacki, Patrick Y. Jay, Stephen A. Huang

Division of Cardiology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: The thyroid hormone-inactivating enzyme type 3 deiodinase (D3) is induced during hypertrophic and ischemic cardiomyopathy, leading to a state of local cardiac hypothyroidism. Whether D3 induction occurs in dilated cardiomyopathy is unknown. Methods: This study characterized changes in cardiac D3 and thyroid hormone signaling in a transgenic model of progressive dilated cardiomyopathy (TG9 mice). Results: Cardiac D3 was dramatically induced 15-fold during the progression of dilated cardiomyopathy in TG9 mice. This D3 induction localized to cardiomyocytes and was associated with a decrease in myocardial thyroid hormone signaling. Conclusions: Cardiac D3 is induced in a mouse model of dilated cardiomyopathy, indicating that D3 induction may be a general response to diverse forms of cardiomyopathy.

Original language	English
Pages (from-to)	732-737
Number of pages	6
Journal	Thyroid
Volume	27
Issue number	5
DOIs	https://doi.org/10.1089/thy.2016.0570
State	Published - May 2017

Keywords

D3
cardiomyopathy
deiodinase
heart
heart failure

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10.1089/thy.2016.0570

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title = "Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy",

abstract = "Background: The thyroid hormone-inactivating enzyme type 3 deiodinase (D3) is induced during hypertrophic and ischemic cardiomyopathy, leading to a state of local cardiac hypothyroidism. Whether D3 induction occurs in dilated cardiomyopathy is unknown. Methods: This study characterized changes in cardiac D3 and thyroid hormone signaling in a transgenic model of progressive dilated cardiomyopathy (TG9 mice). Results: Cardiac D3 was dramatically induced 15-fold during the progression of dilated cardiomyopathy in TG9 mice. This D3 induction localized to cardiomyocytes and was associated with a decrease in myocardial thyroid hormone signaling. Conclusions: Cardiac D3 is induced in a mouse model of dilated cardiomyopathy, indicating that D3 induction may be a general response to diverse forms of cardiomyopathy.",

keywords = "D3, cardiomyopathy, deiodinase, heart, heart failure",

author = "Wassner, {Ari J.} and Jugo, {Rebecca H.} and Dorfman, {David M.} and Padera, {Robert F.} and Maynard, {Michelle A.} and Zavacki, {Ann M.} and Jay, {Patrick Y.} and Huang, {Stephen A.}",

year = "2017",

month = may,

doi = "10.1089/thy.2016.0570",

language = "English",

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T1 - Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy

AU - Wassner, Ari J.

AU - Jugo, Rebecca H.

AU - Dorfman, David M.

AU - Padera, Robert F.

AU - Maynard, Michelle A.

AU - Zavacki, Ann M.

AU - Jay, Patrick Y.

AU - Huang, Stephen A.

PY - 2017/5

Y1 - 2017/5

N2 - Background: The thyroid hormone-inactivating enzyme type 3 deiodinase (D3) is induced during hypertrophic and ischemic cardiomyopathy, leading to a state of local cardiac hypothyroidism. Whether D3 induction occurs in dilated cardiomyopathy is unknown. Methods: This study characterized changes in cardiac D3 and thyroid hormone signaling in a transgenic model of progressive dilated cardiomyopathy (TG9 mice). Results: Cardiac D3 was dramatically induced 15-fold during the progression of dilated cardiomyopathy in TG9 mice. This D3 induction localized to cardiomyocytes and was associated with a decrease in myocardial thyroid hormone signaling. Conclusions: Cardiac D3 is induced in a mouse model of dilated cardiomyopathy, indicating that D3 induction may be a general response to diverse forms of cardiomyopathy.

AB - Background: The thyroid hormone-inactivating enzyme type 3 deiodinase (D3) is induced during hypertrophic and ischemic cardiomyopathy, leading to a state of local cardiac hypothyroidism. Whether D3 induction occurs in dilated cardiomyopathy is unknown. Methods: This study characterized changes in cardiac D3 and thyroid hormone signaling in a transgenic model of progressive dilated cardiomyopathy (TG9 mice). Results: Cardiac D3 was dramatically induced 15-fold during the progression of dilated cardiomyopathy in TG9 mice. This D3 induction localized to cardiomyocytes and was associated with a decrease in myocardial thyroid hormone signaling. Conclusions: Cardiac D3 is induced in a mouse model of dilated cardiomyopathy, indicating that D3 induction may be a general response to diverse forms of cardiomyopathy.

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KW - heart failure

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DO - 10.1089/thy.2016.0570

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Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy

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