Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy

Ari J. Wassner, Rebecca H. Jugo, David M. Dorfman, Robert F. Padera, Michelle A. Maynard, Ann M. Zavacki, Patrick Y. Jay, Stephen A. Huang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: The thyroid hormone-inactivating enzyme type 3 deiodinase (D3) is induced during hypertrophic and ischemic cardiomyopathy, leading to a state of local cardiac hypothyroidism. Whether D3 induction occurs in dilated cardiomyopathy is unknown. Methods: This study characterized changes in cardiac D3 and thyroid hormone signaling in a transgenic model of progressive dilated cardiomyopathy (TG9 mice). Results: Cardiac D3 was dramatically induced 15-fold during the progression of dilated cardiomyopathy in TG9 mice. This D3 induction localized to cardiomyocytes and was associated with a decrease in myocardial thyroid hormone signaling. Conclusions: Cardiac D3 is induced in a mouse model of dilated cardiomyopathy, indicating that D3 induction may be a general response to diverse forms of cardiomyopathy.

Original languageEnglish
Pages (from-to)732-737
Number of pages6
JournalThyroid
Volume27
Issue number5
DOIs
StatePublished - May 2017

Keywords

  • D3
  • cardiomyopathy
  • deiodinase
  • heart
  • heart failure

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