TY - JOUR
T1 - Myocardial Blood Volume Is Associated With Myocardial Oxygen Consumption. An Experimental Study With Cardiac Magnetic Resonance in a Canine Model
AU - McCommis, Kyle S.
AU - Zhang, Haosen
AU - Goldstein, Thomas A.
AU - Misselwitz, Bernd
AU - Abendschein, Dana R.
AU - Gropler, Robert J.
AU - Zheng, Jie
N1 - Funding Information:
This work was supported by NIH grant R01 HL74019-01. Dr. Misselwitz is an employee of Bayer Schering Pharma, which produces the Gadomer contrast agent used in this study.
PY - 2009/11
Y1 - 2009/11
N2 - Understanding the oxygen consumption of the left ventricular myocardium provides important insight into the relationship between myocardial oxygen supply and demand. In other territories, cardiac magnetic resonance has been utilized to measure myocardial oxygen consumption with a blood level oxygen dependent (BOLD) technique. The BOLD technology requires repetitive sampling of stationary tissues and is frequently implemented in areas such as the brain. A limitation to utilizing BOLD cardiac magnetic resonance techniques in the heart has been cardiac motion. In this study, we document a methodology for acquiring BOLD images in the heart and demonstrate the utility of the technique for identifying associations between myocardial oxygen consumption and blood flow.
AB - Understanding the oxygen consumption of the left ventricular myocardium provides important insight into the relationship between myocardial oxygen supply and demand. In other territories, cardiac magnetic resonance has been utilized to measure myocardial oxygen consumption with a blood level oxygen dependent (BOLD) technique. The BOLD technology requires repetitive sampling of stationary tissues and is frequently implemented in areas such as the brain. A limitation to utilizing BOLD cardiac magnetic resonance techniques in the heart has been cardiac motion. In this study, we document a methodology for acquiring BOLD images in the heart and demonstrate the utility of the technique for identifying associations between myocardial oxygen consumption and blood flow.
KW - blood oxygen level dependent
KW - cardiac magnetic resonance
KW - myocardial blood flow
KW - myocardial blood volume
KW - myocardial oxygen consumption
UR - http://www.scopus.com/inward/record.url?scp=70350746488&partnerID=8YFLogxK
U2 - 10.1016/j.jcmg.2009.07.010
DO - 10.1016/j.jcmg.2009.07.010
M3 - Review article
C2 - 19909936
AN - SCOPUS:70350746488
SN - 1936-878X
VL - 2
SP - 1313
EP - 1320
JO - JACC: Cardiovascular Imaging
JF - JACC: Cardiovascular Imaging
IS - 11
ER -