Myocardial Angiogenesis: Its Absence Makes the Growing Heart Founder

Gerald W. Dorn

doi:10.1016/j.cmet.2007.04.003

Myocardial Angiogenesis: Its Absence Makes the Growing Heart Founder

Gerald W. Dorn

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

Angiogenesis is essential for normal and neoplastic tissue growth. In a recent issue of Nature, Komuro and colleagues (Sano et al., 2007) describe how p53 expression in hypertrophying heart muscle impairs HIF-1-mediated neovascularization and contributes to functional decompensation of pressure-overload cardiac hypertrophy.

Original language	English
Pages (from-to)	326-327
Number of pages	2
Journal	Cell metabolism
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2007.04.003
State	Published - May 9 2007

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title = "Myocardial Angiogenesis: Its Absence Makes the Growing Heart Founder",

abstract = "Angiogenesis is essential for normal and neoplastic tissue growth. In a recent issue of Nature, Komuro and colleagues (Sano et al., 2007) describe how p53 expression in hypertrophying heart muscle impairs HIF-1-mediated neovascularization and contributes to functional decompensation of pressure-overload cardiac hypertrophy.",

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AB - Angiogenesis is essential for normal and neoplastic tissue growth. In a recent issue of Nature, Komuro and colleagues (Sano et al., 2007) describe how p53 expression in hypertrophying heart muscle impairs HIF-1-mediated neovascularization and contributes to functional decompensation of pressure-overload cardiac hypertrophy.

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Myocardial Angiogenesis: Its Absence Makes the Growing Heart Founder

Abstract

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