Angiogenesis is essential for normal and neoplastic tissue growth. In a recent issue of Nature, Komuro and colleagues (Sano et al., 2007) describe how p53 expression in hypertrophying heart muscle impairs HIF-1-mediated neovascularization and contributes to functional decompensation of pressure-overload cardiac hypertrophy.

Original languageEnglish
Pages (from-to)326-327
Number of pages2
JournalCell metabolism
Issue number5
StatePublished - May 9 2007


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