Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice

Keyphrases

• Forkhead Box P3 (FOXP3) 100%
• NF-B 100%
• Osteopenia 100%
• Myeloid Lineage 100%
• Scurfy Mice 100%
• Hematopoietic Stem Cells 75%
• C-kit 75%
• Spinocerebellar Ataxia 75%
• Scurfy 75%
• Granulocyte Colony-stimulating Factor (G-CSF) 50%
• Osteoclastogenesis 50%
• Dysregulated 25%
• Mouse Model 25%
• Therapeutic Intervention 25%
• Mammalian Target of Rapamycin (mTOR) 25%
• Bone Marrow 25%
• Gain-of-function mutation 25%
• Flow Cytometric Analysis 25%
• T Helper Cells 25%
• Hyperproliferation 25%
• Pharmacological Inhibitors 25%
• Foxp3+ Regulatory T Cells 25%
• Autoimmune 25%
• Overproduction 25%
• Myeloid Precursors 25%
• Granulocyte-macrophage Progenitor 25%
• Osteoclastogenic Cytokines 25%
• Immune Surveillance 25%
• Osteoclast Progenitors 25%
• PU.1 25%
• IL-17 Signaling Pathway 25%
• Bone Homeostasis 25%
• Severe Bone Loss 25%
• Multi-organ Inflammation 25%
• IPEX Syndrome 25%

Immunology and Microbiology

• Hematopoietic Cell 100%
• Myeloid 100%
• Lineages 100%
• Cytokine 66%
• Macrophage Colony-Stimulating Factor 66%
• Osteoclastogenesis 66%
• Mouse Model 33%
• Regulatory T Cell 33%
• Autoimmunity 33%
• Loss of Function Mutation 33%
• Precursor 33%
• T Helper Cell 33%
• Osteolysis 33%
• Osteoclast 33%
• Upregulation 33%
• Immunosurveillance 33%
• Colony Forming Unit GM 33%
• mTOR Signaling 33%
• IPEX Syndrome 33%
• Interleukin 17 33%
• Bone Homeostasis 33%