Myelinated afferents signal the hyperalgesia associated with nerve injury

James N. Campbell, Srinivasa N. Raja, Richard A. Meyer, Susan E. Mackinnon

Research output: Contribution to journalArticlepeer-review

463 Scopus citations


Pain to light touching of the skin is a hallmark sign of causalgia. The purpose of this study was to determine whether myelinated or unmyelinated afferent fibers signal this hyperalgesia. Sensory testing was performed in 17 patients with long-standing hyperalgesia after nerve injury. The patients underwent a differential ischemie block of nerve function of the involved area. At a time when touch sensation in adjacent normal skin was eliminated, but when sensibility to warming and cooling stimuli was unaffected, the hyperalgesia to mechanical stimuli was abolished in 15 of the subjects. In 2 of these 15 patients, a differential local anesthetic block of the injured nerve was performed proximal to the site of injury. When temperature sensibility was absent, but when touch sensation was intact, hyperalgesia was present. In a third study, latency measurements in response to 400 μm stepped displacement stimuli were made in two patients who had hyperalgesia on the foot. The mean latency for detection of pain in the hyperalgesic region was 414 ± 18 msec, compared to 458 ± 16 msec for the detection of touch to the same stimuli applied to the opposite normal foot. These 3 lines of evidence indicate that myelinated primary afferents, perhaps Aβ fibers, signal the hyperalgesic pain in causalgia. These fibers may be sensitized Aβ nociceptors or low-threshold mechanoreceptors.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
Issue number1
StatePublished - Jan 1988


  • Causalgia
  • Differential nerve block
  • Hyperalgesia
  • Nerve injury
  • Nociceptors
  • Pain


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