Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity

Jonathan Kipnis, Eti Yoles, Tal Mizrahi, Auraham Ben-Nur, Michal Schwartz

Research output: Contribution to journalArticlepeer-review

125 Scopus citations

Abstract

Myelin-specific encephalitogenic T cells, when passively transferred into rats or mice, cause an experimental autoimmune disease. Previous studies by our group have shown that (a) the same cells also significantly reduce post-traumatic degeneration in these animals after injury to the central nervous system, (b) this beneficial autoimmunity is a physiological response, and (c) animals differ in their ability to resist injurious conditions, and the ability to resist post-traumatic degeneration correlates with resistance to the development of an autoimmune disease. Here we show that optic nerve neurons in both resistant and susceptible rat strains can be protected from secondary degeneration after crush injury by immunization with myelin basic protein emulsified in complete or incomplete Freund's adjuvant. We provide evidence that potentially destructive autoimmunity (causing autoimmune disease) and beneficial autoimmunity (causing improved neuronal survival) both result from activity of the same myelin-specific, proinflammatory Th1 cells. We further show that following passive transfer of such Th1 cells, the expression of their beneficial potential depends on the activity of an additional T cell (CD4+) population. By identifying the additional cellular component of autoimmune neuroprotection, we may be able to take meaningful steps toward achieving neuroprotection without risk of accompanying autoimmune disease.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalJournal of Neuroimmunology
Volume130
Issue number1-2
DOIs
StatePublished - Sep 2002

Keywords

  • Myelin specific Th1 cell
  • Neuroprotection
  • Post-traumatic protective autoimmunity

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