Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG)-Positive Optic Perineuritis

A. Sebastian Lopez-Chiriboga; Gregory Van Stavern; Eoin P. Flanagan; Sean J. Pittock; Jim Fryer; M. Tariq Bhatti; John J. Chen

doi:10.1080/01658107.2019.1607883

Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG)-Positive Optic Perineuritis

A. Sebastian Lopez-Chiriboga, Gregory Van Stavern, Eoin P. Flanagan, Sean J. Pittock, Jim Fryer, M. Tariq Bhatti, John J. Chen

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but the majority of cases are idiopathic. Myelin oligodendrocyte glycoprotein (MOG)-IgG-positive optic neuritis has been reported to be associated with optic nerve sheath enhancement. This report describes two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. MOG-IgG may account for many cases of previously described idiopathic optic perineuritis. Vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Neuro-Ophthalmology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1080/01658107.2019.1607883
State	Published - Jan 2 2020

Keywords

Optic perineuritis
aquaporin-4 (AQP4)
myelin oligodendrocyte glycoprotein (MOG)
optic nerve sheath
optic neuritis

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10.1080/01658107.2019.1607883

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title = "Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG)-Positive Optic Perineuritis",

abstract = "Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but the majority of cases are idiopathic. Myelin oligodendrocyte glycoprotein (MOG)-IgG-positive optic neuritis has been reported to be associated with optic nerve sheath enhancement. This report describes two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. MOG-IgG may account for many cases of previously described idiopathic optic perineuritis. Vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG.",

keywords = "Optic perineuritis, aquaporin-4 (AQP4), myelin oligodendrocyte glycoprotein (MOG), optic nerve sheath, optic neuritis",

author = "Lopez-Chiriboga, {A. Sebastian} and {Van Stavern}, Gregory and Flanagan, {Eoin P.} and Pittock, {Sean J.} and Jim Fryer and Bhatti, {M. Tariq} and Chen, {John J.}",

note = "Funding Information: Mayo Clinic foundation, Department of Laboratory Medicine and Pathology and Center for MS and Autoimmune Neurology. The authors thank John Schmeling for technical support, Mary Curtis for secretarial assistance, and Jessica Sagan for study coordination. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Taylor & Francis Group, LLC.",

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language = "English",

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AU - Lopez-Chiriboga, A. Sebastian

AU - Van Stavern, Gregory

AU - Flanagan, Eoin P.

AU - Pittock, Sean J.

AU - Fryer, Jim

AU - Bhatti, M. Tariq

AU - Chen, John J.

N1 - Funding Information: Mayo Clinic foundation, Department of Laboratory Medicine and Pathology and Center for MS and Autoimmune Neurology. The authors thank John Schmeling for technical support, Mary Curtis for secretarial assistance, and Jessica Sagan for study coordination. Publisher Copyright: © 2019, © 2019 Taylor & Francis Group, LLC.

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N2 - Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but the majority of cases are idiopathic. Myelin oligodendrocyte glycoprotein (MOG)-IgG-positive optic neuritis has been reported to be associated with optic nerve sheath enhancement. This report describes two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. MOG-IgG may account for many cases of previously described idiopathic optic perineuritis. Vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG.

AB - Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but the majority of cases are idiopathic. Myelin oligodendrocyte glycoprotein (MOG)-IgG-positive optic neuritis has been reported to be associated with optic nerve sheath enhancement. This report describes two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. MOG-IgG may account for many cases of previously described idiopathic optic perineuritis. Vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG.

KW - Optic perineuritis

KW - aquaporin-4 (AQP4)

KW - myelin oligodendrocyte glycoprotein (MOG)

KW - optic nerve sheath

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Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG)-Positive Optic Perineuritis

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