The transcription factor c-MYC functions as the master transcription factor for establishing highly active metabolic states in proliferating cells. c-Myc is essential for rapid proliferation of normal cells and has causal relationship with many cancers, including leukemia and lymphoma. While the expression of c-MYC can be aberrantly driven by genetic abnormalities, such as chromosomal translocations directly involving the MYC locus or mutations of its upstream regulators, how c-MYC expression is induced and amplified in normal lymphocytes in response to antigen stimulation remains elusive. In this issue of The EMBO Journal, Preston et al (2015) report how c-MYC is selectively induced and amplified in the antigen-specific T cells that undergo massive clonal expansion for host protection against pathogen infection.

Original languageEnglish
Pages (from-to)1990-1991
Number of pages2
JournalEMBO Journal
Issue number15
StatePublished - Aug 4 2015


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