Mutational analysis of ZFY in sporadic parathyroid adenomas

Robert Romano, La Shondra Ellis, Nick Yu, Justin Bellizzi, Taylor C. Brown, Reju Korah, Tobias Carling, Jessica Costa-Guda, Andrew Arnold

Research output: Contribution to journalArticle

Abstract

Context: The molecular pathogenesis of sporadic parathyroid adenomas is incompletely understood, with alterations in cyclin D1/PRAD1 and MEN1 most firmly established as genetic drivers. The gene encoding the X-linked zinc finger protein (ZFX) has recently been implicated in the pathogenesis of a subset of parathyroid adenomas after recurrent, hotspot-focused somatic mutations were identified. ZFX escapes X inactivation and is transcribed from both alleles in women, and a highly homologous gene encoding the Y-linked zinc finger protein (ZFY) provides dosage compensation in males. Objective: We sought to investigate the role of ZFY mutation in sporadic parathyroid adenoma. Intervention: Polymerase chain reaction and Sanger sequencing were used to examine DNA from typically presenting, sporadic (nonfamilial, nonsyndromic) parathyroid adenomas from male patients for mutations within the ZFY gene. Results: No mutations were identified among 117 adenomas. Conclusions: The absence of ZFY mutations in this series suggests that ZFY rarely, if ever, acts as a driver oncogene in sporadic parathyroid adenomas. The apparent differences in tumorigenic capabilities between the closely related zinc finger proteins ZFX and ZFY suggest that structure-function studies could represent an opportunity to gain insight into neoplastic processes in the parathyroid glands.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalJournal of the Endocrine Society
Volume1
Issue number4
DOIs
StatePublished - Apr 2017
Externally publishedYes

Keywords

  • Oncogene
  • Parathyroid
  • ZFX
  • ZFY

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    Romano, R., Ellis, L. S., Yu, N., Bellizzi, J., Brown, T. C., Korah, R., Carling, T., Costa-Guda, J., & Arnold, A. (2017). Mutational analysis of ZFY in sporadic parathyroid adenomas. Journal of the Endocrine Society, 1(4), 313-316. https://doi.org/10.1210/js.2017-00031