Mutation, sequence analysis, and association studies of α-synuclein in Parkinson's disease

A. Parsian, B. Racette, Z. H. Zhang, S. Chakraverty, M. Rundle, A. Goate, J. S. Perlmutter

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

A mutation within the α-synuclein gene on human chromosome 4 has been reported to segregate with PD in an Italian family. We screened a sample of familial cases of PD for mutation in the α-synuclein gene. None of the familial cases of PD carried a mutation within the α-synuclein gene, and no association was detected between PD and alleles of a dinucleotide repeat marker within the α-synuclein gene. We conclude that variation within the α-synuclein gene does not play a significant role in the risk for PD in our sample.

Original languageEnglish
Pages (from-to)1757-1759
Number of pages3
JournalNeurology
Volume51
Issue number6
DOIs
StatePublished - Dec 1998

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