Mutant mouse cerebellum does not provide specific signals for the selective migration and development of transplanted Purkinje cells

Jeffrey V. Rosenfeld; Linda J. Richards; Perry F. Bartlett

doi:10.1016/0304-3940(93)90664-7

Mutant mouse cerebellum does not provide specific signals for the selective migration and development of transplanted Purkinje cells

Jeffrey V. Rosenfeld
, Linda J. Richards
, Perry F. Bartlett

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Embryonic cerebellum transplanted to adult Purkinje cell degenerate mice was assessed for integration and Purkinje cell migration by using the antigenic markers Thy-1 and Leu-4. It was found that the grafted cells migrated into the host's molecular layer, but there was no evidence for specific migration of Purkinje cells. Furthermore, grafted cells were found to form normal cerebellar cyto-architecture only with other grafted cells and not with the host's cells.

Original language	English
Pages (from-to)	19-23
Number of pages	5
Journal	Neuroscience Letters
Volume	155
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(93)90664-7
State	Published - May 28 1993

Keywords

Cerebellum replacement
Neural integration
Neural transplantation
Purkinje cell degenerate mouse
Thy-1

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10.1016/0304-3940(93)90664-7

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title = "Mutant mouse cerebellum does not provide specific signals for the selective migration and development of transplanted Purkinje cells",

abstract = "Embryonic cerebellum transplanted to adult Purkinje cell degenerate mice was assessed for integration and Purkinje cell migration by using the antigenic markers Thy-1 and Leu-4. It was found that the grafted cells migrated into the host's molecular layer, but there was no evidence for specific migration of Purkinje cells. Furthermore, grafted cells were found to form normal cerebellar cyto-architecture only with other grafted cells and not with the host's cells.",

keywords = "Cerebellum replacement, Neural integration, Neural transplantation, Purkinje cell degenerate mouse, Thy-1",

author = "Rosenfeld, \{Jeffrey V.\} and Richards, \{Linda J.\} and Bartlett, \{Perry F.\}",

note = "Funding Information: This work was supported by the National Health and Medical Research Council of Australia. J.R. is a recipient of Peter and Diana Cummings Fellowship of the Research Foundation of the Royal Australasian College of Surgeons.",

year = "1993",

month = may,

day = "28",

doi = "10.1016/0304-3940(93)90664-7",

language = "English",

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journal = "Neuroscience Letters",

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T1 - Mutant mouse cerebellum does not provide specific signals for the selective migration and development of transplanted Purkinje cells

AU - Rosenfeld, Jeffrey V.

AU - Richards, Linda J.

AU - Bartlett, Perry F.

N1 - Funding Information: This work was supported by the National Health and Medical Research Council of Australia. J.R. is a recipient of Peter and Diana Cummings Fellowship of the Research Foundation of the Royal Australasian College of Surgeons.

PY - 1993/5/28

Y1 - 1993/5/28

N2 - Embryonic cerebellum transplanted to adult Purkinje cell degenerate mice was assessed for integration and Purkinje cell migration by using the antigenic markers Thy-1 and Leu-4. It was found that the grafted cells migrated into the host's molecular layer, but there was no evidence for specific migration of Purkinje cells. Furthermore, grafted cells were found to form normal cerebellar cyto-architecture only with other grafted cells and not with the host's cells.

AB - Embryonic cerebellum transplanted to adult Purkinje cell degenerate mice was assessed for integration and Purkinje cell migration by using the antigenic markers Thy-1 and Leu-4. It was found that the grafted cells migrated into the host's molecular layer, but there was no evidence for specific migration of Purkinje cells. Furthermore, grafted cells were found to form normal cerebellar cyto-architecture only with other grafted cells and not with the host's cells.

KW - Cerebellum replacement

KW - Neural integration

KW - Neural transplantation

KW - Purkinje cell degenerate mouse

KW - Thy-1

UR - https://www.scopus.com/pages/publications/0027299708

U2 - 10.1016/0304-3940(93)90664-7

DO - 10.1016/0304-3940(93)90664-7

M3 - Article

C2 - 8361659

AN - SCOPUS:0027299708

SN - 0304-3940

VL - 155

SP - 19

EP - 23

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Mutant mouse cerebellum does not provide specific signals for the selective migration and development of transplanted Purkinje cells

Abstract

Keywords

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