Muscle contractile activity increases fatty acid metabolism and transport and FAT/CD36

Arend Bonen, David J. Dyck, Azeddine Ibrahimi, Nada A. Abumrad

Research output: Contribution to journalArticlepeer-review

156 Scopus citations


We have examined whether 1) fatty acid (FA) uptake, 2) FA transporter expression, and 3) FA metabolism are increased when the oxidative capacity of skeletal muscle is increased. The oxidative capacities of red and white tibialis anterior and extensor digitorum longus muscles were increased via chronic stimulation (10 Hz, 24 h/day for 7 days). The contralateral muscles served as controls. After 7 days of increased muscle activity 1) palmitate uptake by giant sarcolemmal vesicles was increased twofold (P < 0.05), 2) the expression of FA translocase (FAT)/CD36 was increased at both the mRNA (3.2- to 10-fold) and protein (3.4-fold) levels, and 3) palmitate oxidation and esterification into triacylglycerols and phospholipids were increased 1.5-, 2.7-, and 1.7-fold, respectively (P < 0.05). These data show that when the oxidative capacity of muscle is increased, there is a parallel increase in the rate of FA transport and FA transporters at the sarcolemmal membrane, which is associated with the enhanced expression of the membrane transporter FAT/CD36.

Original languageEnglish
Pages (from-to)E642-E649
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number4 39-4
StatePublished - Apr 1999


  • Fatty acid translocase
  • Giant sarcolemmal vesicles
  • Muscle fibers
  • Oxidation
  • Palmitate
  • Phospholipids


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