TY - JOUR
T1 - Murine parainfluenza virus persists in lung innate immune cells sustaining chronic lung pathology
AU - Castro, Ítalo Araújo
AU - Yang, Yanling
AU - Gnazzo, Victoria
AU - Kim, Do Hyun
AU - Van Dyken, Steven J.
AU - Lopez, Carolina
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature Limited 2024. corrected publication 2024.
PY - 2024/11
Y1 - 2024/11
N2 - Common respiratory viruses, including the human parainfluenza viruses, threaten human health seasonally and associate with the development of chronic lung diseases. Evidence suggests that these viruses can persist, but the sources of viral products in vivo and their impact on chronic respiratory diseases remain unknown. Using the murine parainfluenza virus Sendai, we demonstrate that viral protein and RNA persist in lung macrophages, type 2 innate lymphoid cells (ILC2s) and dendritic cells long after the infectious virus is cleared. Cells containing persistent viral protein expressed Th2 inflammation-related transcriptomic signatures associated with the development of chronic lung diseases, including asthma. Lineage tracing demonstrated that distinct functional groups of cells contribute to the chronic pathology. Importantly, targeted ablation of infected cells significantly ameliorated chronic lung disease. Overall, we identified persistent infection of innate immune cells as a key factor in the progression from acute to chronic lung disease after infection with parainfluenza virus.
AB - Common respiratory viruses, including the human parainfluenza viruses, threaten human health seasonally and associate with the development of chronic lung diseases. Evidence suggests that these viruses can persist, but the sources of viral products in vivo and their impact on chronic respiratory diseases remain unknown. Using the murine parainfluenza virus Sendai, we demonstrate that viral protein and RNA persist in lung macrophages, type 2 innate lymphoid cells (ILC2s) and dendritic cells long after the infectious virus is cleared. Cells containing persistent viral protein expressed Th2 inflammation-related transcriptomic signatures associated with the development of chronic lung diseases, including asthma. Lineage tracing demonstrated that distinct functional groups of cells contribute to the chronic pathology. Importantly, targeted ablation of infected cells significantly ameliorated chronic lung disease. Overall, we identified persistent infection of innate immune cells as a key factor in the progression from acute to chronic lung disease after infection with parainfluenza virus.
UR - http://www.scopus.com/inward/record.url?scp=85205348799&partnerID=8YFLogxK
U2 - 10.1038/s41564-024-01805-8
DO - 10.1038/s41564-024-01805-8
M3 - Article
C2 - 39358466
AN - SCOPUS:85205348799
SN - 2058-5276
VL - 9
SP - 2803
EP - 2816
JO - Nature microbiology
JF - Nature microbiology
IS - 11
ER -