TY - JOUR
T1 - Murine Models of Gastric Corpus Preneoplasia
AU - Petersen, Christine P.
AU - Mills, Jason C.
AU - Goldenring, James R.
N1 - Funding Information:
Funding Previously supported by the American Gastroenterological Association Institute Funderburg Award (J.R.G. and J.C.M.). Supported by grants from a Department of Veterans Affairs Merit Review Award (I01BX000930) and National Institutes of Health RO1 DK071590 (J.R.G.); by National Institutes of Health National Research Service Award Predoctoral Fellowship F31 DK104600 (C.P.P.); by National Institutes of Health DK105129, DK094989, and DK052574 to the Washington University Digestive Core Centers, and by a pre-Program Project Award from the Siteman Cancer Center Investment Program (J.C.M.).
Publisher Copyright:
© 2017 The Authors
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Intestinal-type gastric adenocarcinoma evolves in a field of pre-existing metaplasia. Over the past 20 years, a number of murine models have been developed to address aspects of the physiology and pathophysiology of metaplasia induction. Although none of these models has achieved true recapitulation of the induction of adenocarcinoma, they have led to important insights into the factors that influence the induction and progression of metaplasia. Here, we review the pathologic definitions relevant to alterations in gastric corpus lineages and classification of metaplasia by specific lineage markers. In addition, we review present murine models of the induction and progression of spasmolytic polypeptide (TFF2)–expressing metaplasia, the predominant metaplastic lineage observed in murine models. These models provide a basis for the development of a broader understanding of the physiological and pathophysiological roles of metaplasia in the stomach.
AB - Intestinal-type gastric adenocarcinoma evolves in a field of pre-existing metaplasia. Over the past 20 years, a number of murine models have been developed to address aspects of the physiology and pathophysiology of metaplasia induction. Although none of these models has achieved true recapitulation of the induction of adenocarcinoma, they have led to important insights into the factors that influence the induction and progression of metaplasia. Here, we review the pathologic definitions relevant to alterations in gastric corpus lineages and classification of metaplasia by specific lineage markers. In addition, we review present murine models of the induction and progression of spasmolytic polypeptide (TFF2)–expressing metaplasia, the predominant metaplastic lineage observed in murine models. These models provide a basis for the development of a broader understanding of the physiological and pathophysiological roles of metaplasia in the stomach.
KW - Chief Cell
KW - Gastric Cancer
KW - Hyperplasia
KW - Intestinal Metaplasia
KW - SPEM
KW - TFF2
UR - http://www.scopus.com/inward/record.url?scp=85007386692&partnerID=8YFLogxK
U2 - 10.1016/j.jcmgh.2016.11.001
DO - 10.1016/j.jcmgh.2016.11.001
M3 - Review article
C2 - 28174755
AN - SCOPUS:85007386692
VL - 3
SP - 11
EP - 26
JO - CMGH
JF - CMGH
SN - 2352-345X
IS - 1
ER -