Murine FGFR-1 is required for early postimplantation growth and axial organization

Chu Xia Deng, Anthony Wynshaw-Boris, Michael M. Shen, Cathie Daugherty, David M. Ornitz, Philip Leder

Research output: Contribution to journalArticlepeer-review

636 Scopus citations


We have explored the role of fibroblast growth factor receptor 1 (FGFR-1) in early embryonic development using three experimental systems: genetically deficient mice, in vitro blastocyst culture, and FGFR-1-deficient embryonic stem cells. Using these systems, we demonstrate that FGFR-1 is required for proper embryonic cell proliferation and for the correct axial organization of early postimplantation embryos but not for mesoderm formation. FGFR-1- deficient embryos display severe growth retardation both in vitro and in vivo and die prior to or during gastrulation. Although these mutants can form nonaxial tissues, such as the allantois, amnion, and yolk sac mesoderm, they display defective patterning of the primitive streak and other axial structures, and frequently exhibit truncations or disorganization of posterior embryonic regions. Such abnormalities are unlikely to be caused by intrinsic blocks in mesodermal differentiation, as FGFR-1-deficient ES cell lines form teratomas consisting of many mesodermal cell types.

Original languageEnglish
Pages (from-to)3045-3057
Number of pages13
JournalGenes and Development
Issue number24
StatePublished - Dec 15 1994


  • Gene targeting
  • gastrulation
  • mesoderm induction
  • pattern formation


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