Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results

Russell P. Main, Sandra J. Shefelbine, Lee B. Meakin, Matthew J. Silva, Marjolein C.H. van der Meulen, Bettina M. Willie

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

In vivo, tibial loading in mice is increasingly used to study bone adaptation and mechanotransduction. To achieve standardized and defined experimental conditions, loading parameters and animal-related factors must be considered when performing in vivo loading studies. In this review, we discuss these loading and animal-related experimental conditions, present methods to assess bone adaptation, and suggest reporting guidelines. This review originated from presentations by each of the authors at the workshop “Developing Best Practices for Mouse Models of In Vivo Loading” during the Preclinical Models Section at the Orthopaedic Research Society Annual Meeting, San Diego, CA, March 2017. Following the meeting, the authors engaged in detailed discussions with consideration of relevant literature. The guidelines and recommendations in this review are provided to help researchers perform in vivo loading experiments in mice, and thus further our knowledge of bone adaptation and the mechanisms involved in mechanotransduction.

Original languageEnglish
Pages (from-to)233-252
Number of pages20
JournalJournal of Orthopaedic Research
Volume38
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • bone adaptation
  • in vivo mechanical loading
  • tibial loading

Fingerprint Dive into the research topics of 'Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results'. Together they form a unique fingerprint.

  • Cite this