TY - GEN
T1 - Multiscale imaging of the human heart
T2 - 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
AU - Efimov, Igor R.
AU - Fedorov, Vadim V.
AU - Glukhov, Alexey
AU - Lou, Qing
AU - Ambrosi, Christina
AU - Janks, Deborah
AU - Hucker, William J.
AU - Kurian, Thomas
AU - Schuessler, Richard B.
AU - Moazami, Nader
PY - 2010
Y1 - 2010
N2 - The development of human cardiovascular systems physiology is inhibited by the lack of multiscale functional physiological data, which represents human heart physiology at the molecular, cellular, tissue, organ, and system levels. We have developed an experimental approach to study explanted human hearts in vitro at multiple physiological scales with a wide array of imaging modalities. This approach has already yielded data indicating significant differences between animal models of diseases and actual human heart disease. Our data provides a quantitative foundation for multiscale physiological models of the cardiovascular system and will allow improvement in translation of medical technology and pharmacology from animal models to therapy.
AB - The development of human cardiovascular systems physiology is inhibited by the lack of multiscale functional physiological data, which represents human heart physiology at the molecular, cellular, tissue, organ, and system levels. We have developed an experimental approach to study explanted human hearts in vitro at multiple physiological scales with a wide array of imaging modalities. This approach has already yielded data indicating significant differences between animal models of diseases and actual human heart disease. Our data provides a quantitative foundation for multiscale physiological models of the cardiovascular system and will allow improvement in translation of medical technology and pharmacology from animal models to therapy.
UR - http://www.scopus.com/inward/record.url?scp=78650850950&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2010.5626151
DO - 10.1109/IEMBS.2010.5626151
M3 - Conference contribution
C2 - 21095821
AN - SCOPUS:78650850950
SN - 9781424441235
T3 - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
SP - 5177
EP - 5180
BT - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Y2 - 31 August 2010 through 4 September 2010
ER -