@article{6545ed5269b844c4baff23c442f9ff6f,
title = "Multiscale Evolutionary Dynamics of Host-Associated Microbiomes",
abstract = "The composite members of the microbiota face a range of selective pressures and must adapt to persist in the host. We highlight recent work characterizing the evolution and transfer of genetic information across nested scales of host-associated microbiota, which enable resilience to biotic and abiotic perturbations. At the strain level, we consider the preservation and diversification of adaptive information in progeny lineages. At the community level, we consider genetic exchange between distinct microbes in the ecosystem. Finally, we frame microbiomes as open systems subject to acquisition of novel information from foreign ecosystems through invasion by outsider microbes. This review considers mutations in individual microbes, community gene transfer processes and cross-ecosystem information sharing as distinct influences impacting host-associated microbial adaptation in vivo.",
keywords = "clonal interference, colonization, ecology, genomics, horizontal gene transfer, human microbiome, microbial evolution, microbial transmission, pathogen invasion, xenobiotics",
author = "Aura Ferreiro and Nathan Crook and Gasparrini, {Andrew J.} and Gautam Dantas",
note = "Funding Information: This work is supported in part by awards to G.D. through the Edward Mallinckrodt, Jr. Foundation (Scholar Award) and from the National Institute of General Medical Sciences (NIGMS: https://www.nigms.nih.gov/ ), the National Institute of Allergy and Infectious Diseases (NIAID: https://www.niaid.nih.gov/ ), and the Eunice Kennedy Shriver National Institute of Child Health & Human Development ( https://www.nichd.nih.gov/ ) of the National Institutes of Health (NIH) under award numbers R01GM099538 , R01AI123394 , and R01HD092414 , respectively. A.F. received support from the Chancellor{\textquoteright}s Graduate Fellowship Program at Washington University in St. Louis. N.C. received support from the NIDDK Pediatric Gastroenterology Research Training Program of the NIH under award number T32 DK077653 (Phillip I. Tarr, principal investigator). A.J.G. received support from a NIGMS training grant through award number T32 GM007067 (Jim Skeath, principal investigator). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = mar,
day = "8",
doi = "10.1016/j.cell.2018.02.015",
language = "English",
volume = "172",
pages = "1216--1227",
journal = "Cell",
issn = "0092-8674",
number = "6",
}