TY - JOUR
T1 - Multiscale biophysical models of cardiomyopathies reveal complexities challenging existing dogmas
AU - Scott, Brent
AU - Greenberg, Michael J.
N1 - Publisher Copyright:
© 2023 Biophysical Society
PY - 2023/12/19
Y1 - 2023/12/19
N2 - Mutations in sarcomeric proteins, including myosin, cause a variety of cardiomyopathies. A prominent hypothesis has been that myosin mutations causing hypercontractility of the motor lead to hypertrophic cardiomyopathy, while those causing hypocontractility lead to dilated cardiomyopathy; however, recent biophysical studies using multiscale computational and experimental models have revealed complexities not captured by this hypothesis. We summarize recent publications in Biophysical Journal challenging this dogma and highlighting the need for multiscale modeling of these complex diseases.
AB - Mutations in sarcomeric proteins, including myosin, cause a variety of cardiomyopathies. A prominent hypothesis has been that myosin mutations causing hypercontractility of the motor lead to hypertrophic cardiomyopathy, while those causing hypocontractility lead to dilated cardiomyopathy; however, recent biophysical studies using multiscale computational and experimental models have revealed complexities not captured by this hypothesis. We summarize recent publications in Biophysical Journal challenging this dogma and highlighting the need for multiscale modeling of these complex diseases.
UR - http://www.scopus.com/inward/record.url?scp=85178007673&partnerID=8YFLogxK
U2 - 10.1016/j.bpj.2023.11.014
DO - 10.1016/j.bpj.2023.11.014
M3 - Editorial
C2 - 38006882
AN - SCOPUS:85178007673
SN - 0006-3495
VL - 122
SP - 4632
EP - 4634
JO - Biophysical Journal
JF - Biophysical Journal
IS - 24
ER -