TY - JOUR
T1 - Multiple sclerosis-related white matter microstructural change alters the BOLD hemodynamic response
AU - Hubbard, Nicholas A.
AU - Turner, Monroe
AU - Hutchison, Joanna L.
AU - Ouyang, Austin
AU - Strain, Jeremy
AU - Oasay, Larry
AU - Sundaram, Saranya
AU - Davis, Scott
AU - Remington, Gina
AU - Brigante, Ryan
AU - Huang, Hao
AU - Hart, John
AU - Frohman, Teresa
AU - Frohman, Elliot
AU - Biswal, Bharat B.
AU - Rypma, Bart
N1 - Funding Information:
This work was supported by the Friends of Brain Health and the Linda and Joel Roebuck Distinguished New Scientist endowments (to NAH), the National Multiple Sclerosis Society (RG4453A1/2 to BR and EF), and the National Institutes of Health (1R01AG047972 and 1R01AG029523 to BR).
Publisher Copyright:
© The Author(s) 2015.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Multiple sclerosis (MS) results in inflammatory damage to white matter microstructure. Prior research using blood-oxygen-level dependent (BOLD) imaging indicates MS-related alterations to brain function. What is currently unknown is the extent to which white matter microstructural damage influences BOLD signal in MS. Here we assessed changes in parameters of the BOLD hemodynamic response function (HRF) in patients with relapsing-remitting MS compared to healthy controls. We also used diffusion tensor imaging to assess whether MS-related changes to the BOLD-HRF were affected by changes in white matter microstructural integrity. Our results showed MS-related reductions in BOLD-HRF peak amplitude. These MS-related amplitude decreases were influenced by individual differences in white matter microstructural integrity. Other MS-related factors including altered reaction time, limited spatial extent of BOLD activity, elevated lesion burden, or lesion proximity to regions of interest were not mediators of group differences in BOLD-HRF amplitude. Results are discussed in terms of functional hyperemic mechanisms and implications for analysis of BOLD signal differences.
AB - Multiple sclerosis (MS) results in inflammatory damage to white matter microstructure. Prior research using blood-oxygen-level dependent (BOLD) imaging indicates MS-related alterations to brain function. What is currently unknown is the extent to which white matter microstructural damage influences BOLD signal in MS. Here we assessed changes in parameters of the BOLD hemodynamic response function (HRF) in patients with relapsing-remitting MS compared to healthy controls. We also used diffusion tensor imaging to assess whether MS-related changes to the BOLD-HRF were affected by changes in white matter microstructural integrity. Our results showed MS-related reductions in BOLD-HRF peak amplitude. These MS-related amplitude decreases were influenced by individual differences in white matter microstructural integrity. Other MS-related factors including altered reaction time, limited spatial extent of BOLD activity, elevated lesion burden, or lesion proximity to regions of interest were not mediators of group differences in BOLD-HRF amplitude. Results are discussed in terms of functional hyperemic mechanisms and implications for analysis of BOLD signal differences.
KW - Bold contrast
KW - brain imaging
KW - cerebral hemodynamics
KW - multiple sclerosis
KW - white matter disease
UR - http://www.scopus.com/inward/record.url?scp=84994176881&partnerID=8YFLogxK
U2 - 10.1177/0271678X15615133
DO - 10.1177/0271678X15615133
M3 - Article
C2 - 26661225
AN - SCOPUS:84994176881
SN - 0271-678X
VL - 36
SP - 1872
EP - 1884
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 11
ER -