Multiple pathways allow protein secretion across the bacterial outer membrane

David G. Thanassi, Scott J. Hultgren

Research output: Contribution to journalReview articlepeer-review

229 Scopus citations

Abstract

Secretion of proteins across the bacterial outer membrane takes place via a variety of mechanisms from simple one-component systems to complex multicomponent pathways. Secretion pathways can be organized into evolutionarily and functionally related groups, which highlight their relationship with organelle biogenesis. Recent work is beginning to reveal the structure and function of various secretion components and the molecular mechanisms of secretion.

Original languageEnglish
Pages (from-to)420-430
Number of pages11
JournalCurrent Opinion in Cell Biology
Volume12
Issue number4
DOIs
StatePublished - Aug 1 2000

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