Multiple gabaa receptor α subunit mRNAs revealed by developmental and regional expression in rat, chicken and human brain

Pascale Montpied, Edward I. Ginns, Brian M. Martin, Deborah Steuer, Anne Marie O'Carroll, Stephen J. Lolait, Lawrence C. Mahan, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

GABAA receptor α subunit transcripts were detected by Northern analysis of rat, chicken and human brain mRNA using a series of 32 P-labelled antisense RNA probes derived from human α1 subunit cDNAs. These α subunit mRNAs differ in their distribution among various brain regions in the rat and at least one species is detected primarily in fetal brain. GABAA receptor αa subunit probes encoding the putative extracellular domain detect at least five α subunit transcripts in rat brain, whereas probes encoding the putative intracellular domain detect only two mRNAs. These data suggest the presence in brain of multiple GABAA receptor α subunits having homologous extracellular domains and whose expression is regionally and developmentally regulated. These α subunit transcripts may encode proteins that comprise GABAA isoreceptors differing in their pharmacological and physiological properties.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalFEBS Letters
Volume258
Issue number1
DOIs
StatePublished - Nov 20 1989

Keywords

  • (Rat, Chicken, Human, Brain)
  • Developmental expression
  • GABA/benzodiazepine receptor
  • Isoreceptor
  • Multiple α subunit mRNA
  • Regional expression

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