Multiple Cationic Residues of Anthopleurin B That Determine High Affinity and Channel Isoform Discrimination

Keyphrases

• High Affinity 100%
• Na+ Channel 100%
• Site-directed mutagenesis 66%
• Double mutant 66%
• Cardiac Sodium Channel 66%
• Amino Acids 33%
• Biological Activity 33%
• Mutagenesis Studies 33%
• Uptake Assay 33%
• Arginine 33%
• Binding Affinity 33%
• Toxin Activity 33%
• Voltage Clamp 33%
• Closed State 33%
• Reducing Activity 33%
• Voltage-gated Channels 33%
• N1E-115 33%
• Partially Compensated 33%
• Discriminatory Ability 33%
• Open Form 33%
• Veratridine 33%
• C-terminal Lysine 33%
• B-double 33%
• Sodium Uptake 33%
• Sea Anemone Toxin 33%
• Anemone Toxin 33%

Biochemistry, Genetics and Molecular Biology

• Isoform 100%
• Arginine 83%
• Sodium Channel 66%
• Wild Type 16%
• C-Terminus 16%
• Amino Acids 16%
• Electric Potential 16%
• Mutagenesis 16%
• Binding Affinity 16%
• Sea Anemone 16%
• Site-Directed Mutagenesis 16%
• Voltage Clamp 16%
• Sodium Transport 16%
• Anemone 16%
• Lysine 16%
• Veratridine 16%
• Biological Activity 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Anthopleurin A 100%
• Arginine 83%
• Sodium Channel 66%
• Biological Activity 16%
• Amino Acid 16%
• Lysine 16%
• Mutagenesis 16%
• Site-Directed Mutagenesis 16%
• Veratridine 16%
• Anemone 16%
• Sea Anemone Toxin 16%