Multifunctional plasmonic nanorattles for spectrum-guided locoregional therapy

Naveen Gandra; Christopher Portz; Srikanth Singamaneni

doi:10.1002/adma.201302803

Multifunctional plasmonic nanorattles for spectrum-guided locoregional therapy

Naveen Gandra, Christopher Portz, Srikanth Singamaneni

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Locoregional death of cancer cells (in vitro) is induced by ablation of plasmonic nanorattles combined with triggered release of a chemotherapeutic drug from the nanorattles. Completion of the therapy process is indicated by a "Raman signal flip" between the two reporters of the surface-enhanced Raman scattering (SERS) probe. The nanorattles enable targeted delivery of payload and simultaneous monitoring of the payload release and the therapy process.

Original language	English
Pages (from-to)	424-429
Number of pages	6
Journal	Advanced Materials
Volume	26
Issue number	3
DOIs	https://doi.org/10.1002/adma.201302803
State	Published - Jan 22 2014

Keywords

SERS probes
core/shell gold nanostructures
drug delivery
laser ablation
locoregional therapy
nanorattles

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10.1002/adma.201302803

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title = "Multifunctional plasmonic nanorattles for spectrum-guided locoregional therapy",

abstract = "Locoregional death of cancer cells (in vitro) is induced by ablation of plasmonic nanorattles combined with triggered release of a chemotherapeutic drug from the nanorattles. Completion of the therapy process is indicated by a {"}Raman signal flip{"} between the two reporters of the surface-enhanced Raman scattering (SERS) probe. The nanorattles enable targeted delivery of payload and simultaneous monitoring of the payload release and the therapy process.",

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author = "Naveen Gandra and Christopher Portz and Srikanth Singamaneni",

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AU - Portz, Christopher

AU - Singamaneni, Srikanth

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AB - Locoregional death of cancer cells (in vitro) is induced by ablation of plasmonic nanorattles combined with triggered release of a chemotherapeutic drug from the nanorattles. Completion of the therapy process is indicated by a "Raman signal flip" between the two reporters of the surface-enhanced Raman scattering (SERS) probe. The nanorattles enable targeted delivery of payload and simultaneous monitoring of the payload release and the therapy process.

KW - SERS probes

KW - core/shell gold nanostructures

KW - drug delivery

KW - laser ablation

KW - locoregional therapy

KW - nanorattles

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Multifunctional plasmonic nanorattles for spectrum-guided locoregional therapy

Abstract

Keywords

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