Multifunctional FePt nanoparticles for radiation-guided targeting and imaging of cancer

Ghazal Hariri, Matthew S. Wellons, William H. Morris, Charles M. Lukehart, Dennis E. Hallahan

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A multifunctional FePt nanoparticle was developed that targets tumor microvasculature via "radiation-guided" peptides, and is detected by both near-infrared (NIR) fluorescence imaging and analytical mass spectrometry methods. Tumor specific binding was first measured by biotinylated peptide linked to fluorophore-conjugated streptavidin. This showed tumor selective binding to tumors using the HVGGSSV peptide. FePt nanoparticles were synthesized sequentially by surface modification with poly(l)lysine, poly(ethylene) glycol conjugation, and functionalized with HVGGSSV peptide and fluorescent probe Alexa fluor 750. NIR fluorescence imaging and ICP-MS analysis showed significant HVGGSSV-FePt nanoparticle binding to irradiated tumors as compared to unirradiated tumors and controls. Results indicate that multifunctional FePt nanoparticles have potential application for radiation-guided targeting and imaging of cancer.

Original languageEnglish
Pages (from-to)946-952
Number of pages7
JournalAnnals of biomedical engineering
Volume39
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • Magnetic nanoparticles
  • Nanotechnology
  • Radiation
  • Tumor targeting

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