TY - JOUR
T1 - Multifaceted mitochondrial quality control in brown adipose tissue
AU - Aquilano, Katia
AU - Zhou, Beiyan
AU - Brestoff, Jonathan R.
AU - Lettieri-Barbato, Daniele
N1 - Funding Information:
This work was partially supported by the European Foundation for the Study of Diabetes (EFSD/Lilly, 2017 and EFSD/ Boehringer Ingelheim European Research Programme on ‘Multi-system challenges in diabetes’) and the Italian Ministry of Health ( GR-2018-12367588 ) to D.L-B. J.R.B. is supported by the National Institutes of Health (NIH) Office of the Director ( DP5 OD028125 ) and a Burroughs Wellcome Fund Career Award for Medical Scientists (CAMS # 1019648 ). Figures have been created with BioRender.com .
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2023/6
Y1 - 2023/6
N2 - Brown adipose tissue (BAT) controls mammalian core body temperature by non-shivering thermogenesis. BAT is extraordinarily rich in mitochondria, which have the peculiarity of generating heat by uncoupled respiration. Since the mitochondrial activity of BAT is subject to cycles of activation and deactivation in response to environmental temperature changes, an integrated mitochondrial quality control (MQC) system is of fundamental importance to ensure BAT physiology. Here, we provide an overview of the conventional and alternative mechanisms through which thermogenic adipocytes selectively remove damaged parts of mitochondria and how macrophages participate in the MQC system by removing extracellular mitochondrial waste to maintain the thermogenic function of BAT.
AB - Brown adipose tissue (BAT) controls mammalian core body temperature by non-shivering thermogenesis. BAT is extraordinarily rich in mitochondria, which have the peculiarity of generating heat by uncoupled respiration. Since the mitochondrial activity of BAT is subject to cycles of activation and deactivation in response to environmental temperature changes, an integrated mitochondrial quality control (MQC) system is of fundamental importance to ensure BAT physiology. Here, we provide an overview of the conventional and alternative mechanisms through which thermogenic adipocytes selectively remove damaged parts of mitochondria and how macrophages participate in the MQC system by removing extracellular mitochondrial waste to maintain the thermogenic function of BAT.
KW - adipocytes
KW - extracellular vesicles
KW - immune cells
KW - metabolism
KW - mitochondrial transfer
KW - thermogenesis
UR - http://www.scopus.com/inward/record.url?scp=85140098894&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2022.09.008
DO - 10.1016/j.tcb.2022.09.008
M3 - Review article
C2 - 36272883
AN - SCOPUS:85140098894
SN - 0962-8924
VL - 33
SP - 517
EP - 529
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 6
ER -