TY - JOUR
T1 - Multidisciplinary team for the diagnosis and treatment of 2 cases of primary intestinal yolk sac tumor
AU - Huang, Qiujuan
AU - Liu, Changxu
AU - Tang, Ruijun
AU - Li, Jie
AU - Li, Wei
AU - Zhu, Lei
AU - Guo, Yuhong
AU - Zhang, Lin
AU - Qu, Tongyuan
AU - Yang, Lingyi
AU - Li, Lingmei
AU - Wang, Yalei
AU - Sun, Baocun
AU - Meng, Bin
AU - Yan, Jie
AU - Xu, Wengui
AU - Zhang, Huilai
AU - Cao, Dengfeng
AU - Cao, Wenfeng
N1 - Publisher Copyright:
Copyright © 2018 by Cancer Biology & Medicine.
PY - 2018/11
Y1 - 2018/11
N2 - Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. The two patients were a 7-year-old girl and a 29-year-old woman. Both of them preoperatively had an elevated serum alpha fetoprotein (AFP) level (≥ 1,210 ng/mL). The tumors are located in the intestine and imaging examination indicated the rectum as the primary site. Grossly the mass was grey-white and crisp texture. Microscopic examination featured reticular, microcystic, macrocystic, papillary, solid, and some glandular patterns. Immunohistochemically, tumor cells of both cases were positive for SALL4, AFP, pan-cytokeratin (AE1/AE3), and glypican-3. Simultaneously, a stain for EMA, OCT4, CD30, HCG, vimentin and CK20 were negative in all 2 neoplasms. The features of morphology, immunohistochemistry, laboratory examinations and imaging studies consist of the diagnosis of primary yolk sac tumor of the intestine.
AB - Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. The two patients were a 7-year-old girl and a 29-year-old woman. Both of them preoperatively had an elevated serum alpha fetoprotein (AFP) level (≥ 1,210 ng/mL). The tumors are located in the intestine and imaging examination indicated the rectum as the primary site. Grossly the mass was grey-white and crisp texture. Microscopic examination featured reticular, microcystic, macrocystic, papillary, solid, and some glandular patterns. Immunohistochemically, tumor cells of both cases were positive for SALL4, AFP, pan-cytokeratin (AE1/AE3), and glypican-3. Simultaneously, a stain for EMA, OCT4, CD30, HCG, vimentin and CK20 were negative in all 2 neoplasms. The features of morphology, immunohistochemistry, laboratory examinations and imaging studies consist of the diagnosis of primary yolk sac tumor of the intestine.
KW - Extragonadal
KW - Immunohistochemistry
KW - Intestine
KW - Multidisciplinary team (MDT)
KW - Yolk sac tumor
UR - http://www.scopus.com/inward/record.url?scp=85061606211&partnerID=8YFLogxK
U2 - 10.20892/j.issn.2095-3941.2018.0054
DO - 10.20892/j.issn.2095-3941.2018.0054
M3 - Article
C2 - 30766756
AN - SCOPUS:85061606211
SN - 2095-3941
VL - 15
SP - 461
EP - 467
JO - Cancer Biology and Medicine
JF - Cancer Biology and Medicine
IS - 4
ER -