Multidisciplinary team for the diagnosis and treatment of 2 cases of primary intestinal yolk sac tumor

Qiujuan Huang, Changxu Liu, Ruijun Tang, Jie Li, Wei Li, Lei Zhu, Yuhong Guo, Lin Zhang, Tongyuan Qu, Lingyi Yang, Lingmei Li, Yalei Wang, Baocun Sun, Bin Meng, Jie Yan, Wengui Xu, Huilai Zhang, Dengfeng Cao, Wenfeng Cao

Research output: Contribution to journalArticle

Abstract

Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. The two patients were a 7-year-old girl and a 29-year-old woman. Both of them preoperatively had an elevated serum alpha fetoprotein (AFP) level (≥ 1,210 ng/mL). The tumors are located in the intestine and imaging examination indicated the rectum as the primary site. Grossly the mass was grey-white and crisp texture. Microscopic examination featured reticular, microcystic, macrocystic, papillary, solid, and some glandular patterns. Immunohistochemically, tumor cells of both cases were positive for SALL4, AFP, pan-cytokeratin (AE1/AE3), and glypican-3. Simultaneously, a stain for EMA, OCT4, CD30, HCG, vimentin and CK20 were negative in all 2 neoplasms. The features of morphology, immunohistochemistry, laboratory examinations and imaging studies consist of the diagnosis of primary yolk sac tumor of the intestine.

Original languageEnglish
Pages (from-to)461-467
Number of pages7
JournalCancer Biology and Medicine
Volume15
Issue number4
DOIs
StatePublished - Nov 2018

Keywords

  • Extragonadal
  • Immunohistochemistry
  • Intestine
  • Multidisciplinary team (MDT)
  • Yolk sac tumor

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    Huang, Q., Liu, C., Tang, R., Li, J., Li, W., Zhu, L., Guo, Y., Zhang, L., Qu, T., Yang, L., Li, L., Wang, Y., Sun, B., Meng, B., Yan, J., Xu, W., Zhang, H., Cao, D., & Cao, W. (2018). Multidisciplinary team for the diagnosis and treatment of 2 cases of primary intestinal yolk sac tumor. Cancer Biology and Medicine, 15(4), 461-467. https://doi.org/10.20892/j.issn.2095-3941.2018.0054