Multi-scale assessments of cardiac electrophysiology reveal regional heterogeneity in health and disease

Catherine E. Lipovsky; Brittany D. Brumback; Aditi Khandekar; Stacey L. Rentschler

doi:10.3390/jcdd5010016

Multi-scale assessments of cardiac electrophysiology reveal regional heterogeneity in health and disease

Catherine E. Lipovsky, Brittany D. Brumback, Aditi Khandekar, Stacey L. Rentschler

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac electrophysiology that persists into adulthood. Here, we discuss regional specific electrical responses to genetic mutations and cardiac stressors, their clinical correlations, and describe many of the multi-scale techniques commonly used to analyze electrophysiological regional heterogeneity.

Original language	English
Article number	16
Journal	Journal of Cardiovascular Development and Disease
Volume	5
Issue number	1
DOIs	https://doi.org/10.3390/jcdd5010016
State	Published - Mar 1 2018

Keywords

Cardiac development
ECGI
Electrophysiology
Optical mapping

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10.3390/jcdd5010016

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KW - Optical mapping

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Multi-scale assessments of cardiac electrophysiology reveal regional heterogeneity in health and disease

Abstract

Keywords

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