Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1- 13C]pyruvate

Cornelius Von Morze, Galen Reed, Peter Shin, Peder E.Z. Larson, Simon Hu, Robert Bok, Daniel B. Vigneron

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A new method was developed for simultaneous spatial localization and spectral separation of multiple compounds based on a single echo, by designing the acquisition to place individual compounds in separate frequency encoding bands. This method was specially designed for rapid and robust metabolic imaging of hyperpolarized 13C substrates and their metabolic products, and was investigated in phantom studies and studies in normal mice and transgenic models of prostate cancer to provide rapid metabolic imaging of hyperpolarized [1- 13C]pyruvate and its metabolic products [1- 13C]lactate and [1- 13C]alanine at spatial resolutions up to 3 mm in-plane. Elevated pyruvate and lactate signals in the vicinity of prostatic tissues were observed in transgenic tumor mice. The multi-band frequency encoding technique enabled rapid metabolic imaging of hyperpolarized 13C compounds with important advantages over prior approaches, including less complicated acquisition and reconstruction methods.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalJournal of Magnetic Resonance
Volume211
Issue number2
DOIs
StatePublished - Aug 2011

Keywords

  • C13
  • Hyperpolarized
  • MRSI
  • Preclinical
  • TRAMP

Fingerprint

Dive into the research topics of 'Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1- 13C]pyruvate'. Together they form a unique fingerprint.

Cite this