@article{6e82c9768e5f4d1689529f3f6c53c82b,
title = "Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation",
abstract = "We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 × 10−9), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background.",
author = "FinnGen and {eMERGE Consortium} and Anubha Mahajan and Spracklen, {Cassandra N.} and Weihua Zhang and Ng, {Maggie C.Y.} and Petty, {Lauren E.} and Hidetoshi Kitajima and Yu, {Grace Z.} and Sina R{\"u}eger and Leo Speidel and Kim, {Young Jin} and Momoko Horikoshi and Mercader, {Josep M.} and Daniel Taliun and Sanghoon Moon and Kwak, {Soo Heon} and Robertson, {Neil R.} and Rayner, {Nigel W.} and Marie Loh and Kim, {Bong Jo} and Joshua Chiou and Irene Miguel-Escalada and {della Briotta Parolo}, Pietro and Kuang Lin and Fiona Bragg and Preuss, {Michael H.} and Fumihiko Takeuchi and Jana Nano and Xiuqing Guo and Amel Lamri and Masahiro Nakatochi and Scott, {Robert A.} and Lee, {Jung Jin} and Alicia Huerta-Chagoya and Mariaelisa Graff and Chai, {Jin Fang} and Parra, {Esteban J.} and Jie Yao and Bielak, {Lawrence F.} and Yasuharu Tabara and Yang Hai and Valgerdur Steinthorsdottir and Cook, {James P.} and Mart Kals and Niels Grarup and Schmidt, {Ellen M.} and Ian Pan and Tamar Sofer and Matthias Wuttke and Chloe Sarnowski and Christian Gieger and Darryl Nousome and Stella Trompet and Jirong Long and Meng Sun and Lin Tong and Chen, {Wei Min} and Meraj Ahmad and Raymond Noordam and Lim, {Victor J.Y.} and Tam, {Claudia H.T.} and Joo, {Yoonjung Yoonie} and Chen, {Chien Hsiun} and Raffield, {Laura M.} and C{\'e}cile Lecoeur and Prins, {Bram Peter} and Aude Nicolas and Yanek, {Lisa R.} and Guanjie Chen and Jensen, {Richard A.} and Salman Tajuddin and Kabagambe, {Edmond K.} and Ping An and Xiang, {Anny H.} and Choi, {Hyeok Sun} and Cade, {Brian E.} and Jingyi Tan and Jack Flanagan and Fernando Abaitua and Adair, {Linda S.} and Adebowale Adeyemo and Aguilar-Salinas, {Carlos A.} and Masato Akiyama and Anand, {Sonia S.} and Alain Bertoni and Zheng Bian and Jette Bork-Jensen and Ivan Brandslund and Brody, {Jennifer A.} and Brummett, {Chad M.} and Buchanan, {Thomas A.} and Micka{\"e}l Canouil and Chan, {Juliana C.N.} and Chang, {Li Ching} and Chee, {Miao Li} and Ji Chen and Chen, {Shyh Huei} and Chen, {Yuan Tsong} and Zhengming Chen and Chuang, {Lee Ming} and Mary Cushman and Das, {Swapan K.} and {de Silva}, {H. Janaka} and George Dedoussis and Latchezar Dimitrov and Doumatey, {Ayo P.} and Shufa Du and Qing Duan and Eckardt, {Kai Uwe} and Emery, {Leslie S.} and Evans, {Daniel S.} and Evans, {Michele K.} and Krista Fischer and Floyd, {James S.} and Ian Ford and Myriam Fornage and Franco, {Oscar H.} and Frayling, {Timothy M.} and Freedman, {Barry I.} and Christian Fuchsberger and Pauline Genter and Gerstein, {Hertzel C.} and Vilmantas Giedraitis and Clicerio Gonz{\'a}lez-Villalpando and Gonz{\'a}lez-Villalpando, {Maria Elena} and Goodarzi, {Mark O.} and Penny Gordon-Larsen and David Gorkin and Myron Gross and Yu Guo and Sophie Hackinger and Sohee Han and Hattersley, {Andrew T.} and Christian Herder and Howard, {Annie Green} and Willa Hsueh and Mengna Huang and Wei Huang and Hung, {Yi Jen} and Hwang, {Mi Yeong} and Hwu, {Chii Min} and Sahoko Ichihara and Ikram, {Mohammad Arfan} and Martin Ingelsson and Islam, {Md Tariqul} and Masato Isono and Jang, {Hye Mi} and Farzana Jasmine and Guozhi Jiang and Jonas, {Jost B.} and J{\o}rgensen, {Marit E.} and Torben J{\o}rgensen and Yoichiro Kamatani and Kandeel, {Fouad R.} and Anuradhani Kasturiratne and Tomohiro Katsuya and Varinderpal Kaur and Takahisa Kawaguchi and Keaton, {Jacob M.} and Kho, {Abel N.} and Khor, {Chiea Chuen} and Kibriya, {Muhammad G.} and Kim, {Duk Hwan} and Katsuhiko Kohara and Jennifer Kriebel and Florian Kronenberg and Johanna Kuusisto and Kristi L{\"a}ll and Lange, {Leslie A.} and Lee, {Myung Shik} and Lee, {Nanette R.} and Aaron Leong and Liming Li and Yun Li and Ruifang Li-Gao and Symen Ligthart and Lindgren, {Cecilia M.} and Allan Linneberg and Liu, {Ching Ti} and Jianjun Liu and Locke, {Adam E.} and Tin Louie and Jian{\textquoteright}an Luan and Luk, {Andrea O.} and Xi Luo and Jun Lv and Valeriya Lyssenko and Vasiliki Mamakou and Mani, {K. Radha} and Thomas Meitinger and Andres Metspalu and Morris, {Andrew D.} and Nadkarni, {Girish N.} and Nadler, {Jerry L.} and Nalls, {Michael A.} and Uma Nayak and Nongmaithem, {Suraj S.} and Ioanna Ntalla and Yukinori Okada and Lorena Orozco and Province, {Michael A.}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2022",
month = may,
day = "1",
doi = "10.1038/s41588-022-01058-3",
language = "English",
volume = "54",
pages = "560--572",
journal = "Nature Genetics",
issn = "1061-4036",
number = "5",
}