Mucosal impedance for esophageal disease: evaluating the evidence

John O. Clarke, Nitin K. Ahuja, Walter W. Chan, C. Prakash Gyawali, Jennifer L. Horsley-Silva, Afrin N. Kamal, Marcelo F. Vela, Yinglian Xiao

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Impedance has traditionally been employed in esophageal disease as a means to assess bolus flow and reflux episodes. Recent and ongoing research has provided new and novel applications for this technology. Measurement of esophageal mucosal impedance, via either multichannel intraluminal impedance catheters or specially designed endoscopically deployed impedance catheters, provides a marker of mucosal integrity. Mucosal impedance has been shown to segregate gastroesophageal reflux disease (GERD) and eosinophilic esophagitis from non-GERD controls and may play a role in predicting response to reflux intervention. More data are needed with regard to other esophageal subgroups, outcome studies, and functional disease. Our paper reviews the history of impedance in esophageal disease, the means of assessing baseline and mucosal impedance, data with regard to the newly developed mucosal impedance probes, the clinical utility of mucosal impedance in specific clinical conditions, and limitations in our existing knowledge, along with suggestions for future studies.

Original languageEnglish
Pages (from-to)247-257
Number of pages11
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Nov 10 2020


  • achalasia
  • eosinophilic esophagitis
  • gastroesophageal reflux disease (GERD)
  • impedance
  • mucosal impedance
  • mucosal integrity


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