TY - JOUR
T1 - Muco-cutaneous leishmaniasis in the New World
T2 - The ultimate subversion
AU - Ronet, Catherine
AU - Beverley, Stephen M.
AU - Fasel, Nicolas
N1 - Funding Information:
ute to amelioration of disease severity. The funded by the grants FNRS N° 3100A0-ent experimental conditions. J Parasitol 1988;
PY - 2011
Y1 - 2011
N2 - Infection by the human protozoan parasite Leishmania can lead, depending primarily on the parasite species, to either cutaneous or mucocutaneous lesions, or fatal generalized visceral infection. In the New World, Leishmania (Viannia) species can cause mucocutaneous leishmaniasis (MCL). Clinical MCL involves a strong hyper-inflammatory response and parasitic dissemination (metastasis) from a primary lesion to distant sites, leading to destructive metastatic secondary lesions especially in the nasopharyngal areas. Recently, we reported that metastasizing, but not non-metastatic strains of Leishmania (Viannia) guyanensis, have high burden of a non-segmented dsRNA virus, Leishmania RNA Virus (LRV). Viral dsRNA is sensed by the host Toll-like Receptor 3 (TLR3) thereby inducing a pro-inflammatory response and exacerbating the disease. The presence of LRV in Leishmania opens new perspectives not only in basic understanding of the intimate relation between the parasite and LRV, but also in understanding the importance of the inflammatory response in MCL patients.
AB - Infection by the human protozoan parasite Leishmania can lead, depending primarily on the parasite species, to either cutaneous or mucocutaneous lesions, or fatal generalized visceral infection. In the New World, Leishmania (Viannia) species can cause mucocutaneous leishmaniasis (MCL). Clinical MCL involves a strong hyper-inflammatory response and parasitic dissemination (metastasis) from a primary lesion to distant sites, leading to destructive metastatic secondary lesions especially in the nasopharyngal areas. Recently, we reported that metastasizing, but not non-metastatic strains of Leishmania (Viannia) guyanensis, have high burden of a non-segmented dsRNA virus, Leishmania RNA Virus (LRV). Viral dsRNA is sensed by the host Toll-like Receptor 3 (TLR3) thereby inducing a pro-inflammatory response and exacerbating the disease. The presence of LRV in Leishmania opens new perspectives not only in basic understanding of the intimate relation between the parasite and LRV, but also in understanding the importance of the inflammatory response in MCL patients.
KW - Hyperinflammation
KW - IFNβ
KW - Leishmania RNA virus
KW - Leishmaniasis
KW - TLR-3
UR - http://www.scopus.com/inward/record.url?scp=82955168459&partnerID=8YFLogxK
U2 - 10.4161/viru.2.6.17839
DO - 10.4161/viru.2.6.17839
M3 - Article
C2 - 21971185
AN - SCOPUS:82955168459
SN - 2150-5594
VL - 2
SP - 547
EP - 552
JO - Virulence
JF - Virulence
IS - 6
ER -