Mucin-type O-glycosylation is critical for vascular integrity

Brett H. Herzog, Jianxin Fu, Lijun Xia

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Vascular endothelial cells, in addition to many other mammalian cell types, express proteins that are highly modified with mucin-type O-glycosylation, a specific type of glycosylation that begins with the addition of an N-acetylgalactosamine moiety to serine or threonine residues within the peptide backbone. Recently, it has become evident that O-glycosylation governs the separation of blood and lymphatic vessels throughout life and plays a critical role in maintaining vascular integrity in specific tissues such as the brain and lymph node. This mini-review seeks to highlight some of these recent advances regarding in vivo functions of mucintype O-glycans.

Original languageEnglish
Pages (from-to)1237-1241
Number of pages5
JournalGlycobiology
Volume24
Issue number12
DOIs
StatePublished - Dec 1 2014

Keywords

  • Clec-2
  • O-glycosylation
  • Platelet
  • Podoplanin
  • Vascular integrity

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