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MTORC1 controls fasting-induced ketogenesis and its modulation by ageing
Shomit Sengupta
, Timothy R. Peterson
, Mathieu Laplante
, Stephanie Oh
, David M. Sabatini
Division of Bone & Mineral Diseases
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Institute of Clinical and Translational Sciences (ICTS)
Siteman Cancer Center
DBBS - Plant and Microbial Biosciences
DBBS - Computational and Systems Biology
DBBS - Biomedical Informatics and Data Science
DBBS - Molecular Genetics and Genomics
Research output
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Contribution to journal
›
Article
›
peer-review
557
Scopus citations
Overview
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Keyphrases
Mammalian Target of Rapamycin (mTOR)
100%
Aging
100%
Ketogenesis
100%
Liver
38%
Peroxisome Proliferator-activated Receptor
23%
Ketogenic
15%
TSC1
7%
Cell Growth
7%
Gene Expression
7%
Induced Activation
7%
Ketones
7%
Transcriptional Repressor
7%
Associated Proteins
7%
Opposite Effects
7%
Specific Loss Power
7%
Corepressor
7%
Suppression Effect
7%
Energy Sources
7%
Aged Mice
7%
Peripheral Tissues
7%
Raptor
7%
Induced Defects
7%
Liver Size
7%
Liver-specific
7%
Ketone Bodies
7%
Nuclear Receptor Corepressor
7%
Liver Physiology
7%
Ketone Body Metabolism
7%
Biochemistry, Genetics and Molecular Biology
Mammalian Target of Rapamycin Complex 1
100%
Ketogenesis
100%
Peroxisome Proliferator-Activated Receptor
27%
Gene Expression
9%
Cell Growth
9%
Kinase
9%
Phosphotransferase
9%
Corepressor
9%
Transcriptional Activator
9%
Tuberous Sclerosis
9%
Liver Size
9%
Regulatory Associated Protein of mTOR
9%
Nuclear Receptor Co-Repressor 1
9%
Ketone Bodies
9%