Oncogene-induced senescence (OIS) is thought to be a barrier to malignant transformation resulting from the strong activation of oncogenes. In this issue of Cancer Cell, Damsky and colleagues suggest activation of mTORC1 and mTORC2 is required for OIS evasion in human melanomas harboring oncogenic BRAF mutations.

Original languageEnglish
Pages (from-to)3-5
Number of pages3
JournalCancer Cell
Issue number1
StatePublished - 2015


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