mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels

Alice Butler, Susan Tsunoda, David P. McCobb, Aguan Wei, Lawrence Salkoff

Research output: Contribution to journalArticlepeer-review

549 Scopus citations

Abstract

Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled "maxi" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalScience
Volume261
Issue number5118
DOIs
StatePublished - Jul 9 1993

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