The β-globin gene of a patient with mRNA-deficient β°-thalassemia has been sequenced. We find a single nucleotide deletion in amino acid codon 44 that produces a UGA terminator at codon 60. We have previously shown that the β-globin mRNA of this patient is correctly spliced and polyadenylated, but rapidly turns over with a half-life of less than 30 min. We suggest that the rapid mRNA turnover is influenced by the deletion of this single nucleotide as well as by the nonsense codon.

Original languageEnglish
Pages (from-to)5421-5427
Number of pages7
JournalNucleic acids research
Issue number18
StatePublished - Sep 25 1982


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