TY - JOUR
T1 - MRI tools for assessment of microstructure and nephron function of the kidney
AU - Xie, Luke
AU - Bennett, Kevin M.
AU - Liu, Chunlei
AU - Johnson, G. Allan
AU - Zhang, Jeff Lei
AU - Lee, Vivian S.
N1 - Funding Information:
This work was supported in part by the American Heart Association (12BGIA9840020 to K. Bennett), Diabetic Complications Consortium (to K. Bennett), National Institute of Mental Health (R01 MH096979 to C. Liu), National Institute of Biomedical Imaging and Bioengineering (P41 EB015897 to G. Johnson), National Institutes of Health Office of the Director (S10 OD010683 to G. Johnson), and National Institute of Diabetes and Digestive and Kidney Diseases (DK091722 to K. Bennett, DK063183 to V. Lee, and DK088375 to V. Lee).
Publisher Copyright:
© 2016 the American Physiological Society.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - MRI can provide excellent detail of renal structure and function. Recently, novel MR contrast mechanisms and imaging tools have been developed to evaluate microscopic kidney structures including the tubules and glomeruli. Quantitative MRI can assess local tubular function and is able to determine the concentrating mechanism of the kidney noninvasively in real time. Measuring single nephron function is now a near possibility. In parallel to advancing imaging techniques for kidney microstructure is a need to carefully understand the relationship between the local source of MRI contrast and the underlying physiological change. The development of these imaging markers can impact the accurate diagnosis and treatment of kidney disease. This study reviews the novel tools to examine kidney microstructure and local function and demonstrates the application of these methods in renal pathophysiology.
AB - MRI can provide excellent detail of renal structure and function. Recently, novel MR contrast mechanisms and imaging tools have been developed to evaluate microscopic kidney structures including the tubules and glomeruli. Quantitative MRI can assess local tubular function and is able to determine the concentrating mechanism of the kidney noninvasively in real time. Measuring single nephron function is now a near possibility. In parallel to advancing imaging techniques for kidney microstructure is a need to carefully understand the relationship between the local source of MRI contrast and the underlying physiological change. The development of these imaging markers can impact the accurate diagnosis and treatment of kidney disease. This study reviews the novel tools to examine kidney microstructure and local function and demonstrates the application of these methods in renal pathophysiology.
KW - Cationized ferritin agents
KW - Gadolinium-based contrast agent
KW - Glomerular microstructure
KW - Kidney concentrating mechanism
KW - Kidney microstructure
KW - Magnetic resonance imaging
KW - Nephron architecture
KW - Quantitative susceptibility mapping
KW - Susceptibility tensor imaging
UR - http://www.scopus.com/inward/record.url?scp=85002966857&partnerID=8YFLogxK
U2 - 10.1152/ajprenal.00134.2016
DO - 10.1152/ajprenal.00134.2016
M3 - Review article
C2 - 27630064
AN - SCOPUS:85002966857
SN - 1931-857X
VL - 311
SP - F1109-F1124
JO - American Journal of Physiology - Renal Physiology
JF - American Journal of Physiology - Renal Physiology
IS - 6
ER -