MRI Signal Intensity and Parkinsonism in Manganese-Exposed Workers

Susan R. Criswell; Susan Searles Nielsen; Mark N. Warden; Hubert P. Flores; Jason Lenox-Krug; Sophia Racette; Lianne Sheppard; Harvey Checkoway; Brad A. Racette

doi:10.1097/JOM.0000000000001634

MRI Signal Intensity and Parkinsonism in Manganese-Exposed Workers

Susan R. Criswell, Susan Searles Nielsen, Mark N. Warden, Hubert P. Flores, Jason Lenox-Krug, Sophia Racette, Lianne Sheppard, Harvey Checkoway, Brad A. Racette

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia provides a noninvasive measure of manganese (Mn) exposure, and may also represent a biomarker for clinical neurotoxicity.Methods:We acquired T1-weighted MRI scans in 27 Mn-exposed welders, 12 other Mn-exposed workers, and 29 nonexposed participants. T1-weighted intensity indices were calculated for four basal ganglia regions. Cumulative Mn exposure was estimated from work history data. Participants were examined using the Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3).Results:We observed a positive dose-response association between cumulative Mn exposure and the pallidal index (PI) (β=2.33; 95% confidence interval [CI], 0.93 to 3.74). There was a positive relationship between the PI and UPDRS3 (β=0.15; 95% CI, 0.03 to 0.27).Conclusion:The T1-weighted pallidal signal is associated with occupational Mn exposure and severity of parkinsonism.

Original language	English
Pages (from-to)	641-645
Number of pages	5
Journal	Journal of occupational and environmental medicine
Volume	61
Issue number	8
DOIs	https://doi.org/10.1097/JOM.0000000000001634
State	Published - Aug 1 2019

Keywords

MRI
parkinsonism
welding

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10.1097/JOM.0000000000001634

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@article{e900941efc1c44cfbcccb5bd475d2023,

title = "MRI Signal Intensity and Parkinsonism in Manganese-Exposed Workers",

abstract = "T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia provides a noninvasive measure of manganese (Mn) exposure, and may also represent a biomarker for clinical neurotoxicity.Methods:We acquired T1-weighted MRI scans in 27 Mn-exposed welders, 12 other Mn-exposed workers, and 29 nonexposed participants. T1-weighted intensity indices were calculated for four basal ganglia regions. Cumulative Mn exposure was estimated from work history data. Participants were examined using the Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3).Results:We observed a positive dose-response association between cumulative Mn exposure and the pallidal index (PI) (β=2.33; 95% confidence interval [CI], 0.93 to 3.74). There was a positive relationship between the PI and UPDRS3 (β=0.15; 95% CI, 0.03 to 0.27).Conclusion:The T1-weighted pallidal signal is associated with occupational Mn exposure and severity of parkinsonism.",

keywords = "MRI, parkinsonism, welding",

author = "Criswell, {Susan R.} and Nielsen, {Susan Searles} and Warden, {Mark N.} and Flores, {Hubert P.} and Jason Lenox-Krug and Sophia Racette and Lianne Sheppard and Harvey Checkoway and Racette, {Brad A.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Occupational and Environmental Medicine.",

year = "2019",

month = aug,

day = "1",

doi = "10.1097/JOM.0000000000001634",

language = "English",

volume = "61",

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journal = "Journal of occupational and environmental medicine",

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T1 - MRI Signal Intensity and Parkinsonism in Manganese-Exposed Workers

AU - Criswell, Susan R.

AU - Nielsen, Susan Searles

AU - Warden, Mark N.

AU - Flores, Hubert P.

AU - Lenox-Krug, Jason

AU - Racette, Sophia

AU - Sheppard, Lianne

AU - Checkoway, Harvey

AU - Racette, Brad A.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia provides a noninvasive measure of manganese (Mn) exposure, and may also represent a biomarker for clinical neurotoxicity.Methods:We acquired T1-weighted MRI scans in 27 Mn-exposed welders, 12 other Mn-exposed workers, and 29 nonexposed participants. T1-weighted intensity indices were calculated for four basal ganglia regions. Cumulative Mn exposure was estimated from work history data. Participants were examined using the Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3).Results:We observed a positive dose-response association between cumulative Mn exposure and the pallidal index (PI) (β=2.33; 95% confidence interval [CI], 0.93 to 3.74). There was a positive relationship between the PI and UPDRS3 (β=0.15; 95% CI, 0.03 to 0.27).Conclusion:The T1-weighted pallidal signal is associated with occupational Mn exposure and severity of parkinsonism.

AB - T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia provides a noninvasive measure of manganese (Mn) exposure, and may also represent a biomarker for clinical neurotoxicity.Methods:We acquired T1-weighted MRI scans in 27 Mn-exposed welders, 12 other Mn-exposed workers, and 29 nonexposed participants. T1-weighted intensity indices were calculated for four basal ganglia regions. Cumulative Mn exposure was estimated from work history data. Participants were examined using the Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3).Results:We observed a positive dose-response association between cumulative Mn exposure and the pallidal index (PI) (β=2.33; 95% confidence interval [CI], 0.93 to 3.74). There was a positive relationship between the PI and UPDRS3 (β=0.15; 95% CI, 0.03 to 0.27).Conclusion:The T1-weighted pallidal signal is associated with occupational Mn exposure and severity of parkinsonism.

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EP - 645

JO - Journal of occupational and environmental medicine

JF - Journal of occupational and environmental medicine

IS - 8

ER -

MRI Signal Intensity and Parkinsonism in Manganese-Exposed Workers

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