MRI measurement of liver regeneration in mice following partial hepatectomy

Joel R. Garbow, M. Kataoka, M. W. Flye

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Improvements in noninvasive imaging modalities are crucial for preoperative in vivo assessments of liver condition and potential for regeneration after liver resection for removal of liver tumors. To that end, an MRI study of liver regeneration in mice following partial hepatectomy is described and validated. Hepatic volumes were accurately measured from contrast-enhanced, gradient-echo images of the liver. Regeneration curves were constructed for a series of mice (N = 6) from a longitudinal MR study, with images collected 1,2,3,4,5, and 9 days following surgery. We validated the MR method by correlating serial MR-measured volumes with liver wet weight. The success of this method will enable future studies to better elucidate the factors that affect regeneration, and help to optimize the timing and dosing of chemotherapeutics to minimize their deleterious effects on liver regeneration.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalMagnetic resonance in medicine
Volume52
Issue number1
DOIs
StatePublished - Jul 2004

Keywords

  • Cancer
  • Hepatectomy
  • Liver regeneration
  • Liver tumors
  • MRI

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