Purpose: Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors are refractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will have a positive impact on the outcome of these patients. Methods: We report on two illustrated cases of pediatric NF1- associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy (LITT). Results: Both tumors responded favorably to LITT. Conclusion: LITT should be considered as a treatment option for chemoresistant deep-seated NF1-associated low-grade gliomas.

Original languageEnglish
JournalChild's Nervous System
StateAccepted/In press - 2022


  • Deep-seated gliomas
  • Laser interstitial thermal therapy
  • Neurofibromatosis type 1
  • Thalamic tumors


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