MRI-guided laser interstitial thermal therapy for deep-seated gliomas in children with neurofibromatosis type 1: report of two cases

Kevin A. Cross; Afshin Salehi; Mohamed S. Abdelbaki; David H. Gutmann; David D. Limbrick

doi:10.1007/s00381-022-05660-y

MRI-guided laser interstitial thermal therapy for deep-seated gliomas in children with neurofibromatosis type 1: report of two cases

Kevin A. Cross, Afshin Salehi, Mohamed S. Abdelbaki, David H. Gutmann, David D. Limbrick

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Purpose: Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors are refractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will have a positive impact on the outcome of these patients. Methods: We report on two illustrated cases of pediatric NF1- associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy (LITT). Results: Both tumors responded favorably to LITT. Conclusion: LITT should be considered as a treatment option for chemoresistant deep-seated NF1-associated low-grade gliomas.

Original language	English
Journal	Child's Nervous System
DOIs	https://doi.org/10.1007/s00381-022-05660-y
State	Accepted/In press - 2022

Keywords

Deep-seated gliomas
Laser interstitial thermal therapy
Neurofibromatosis type 1
Thalamic tumors

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10.1007/s00381-022-05660-y

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@article{247093e1f3f14977aca85cba7bc540fa,

title = "MRI-guided laser interstitial thermal therapy for deep-seated gliomas in children with neurofibromatosis type 1: report of two cases",

abstract = "Purpose: Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors are refractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will have a positive impact on the outcome of these patients. Methods: We report on two illustrated cases of pediatric NF1- associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy (LITT). Results: Both tumors responded favorably to LITT. Conclusion: LITT should be considered as a treatment option for chemoresistant deep-seated NF1-associated low-grade gliomas.",

keywords = "Deep-seated gliomas, Laser interstitial thermal therapy, Neurofibromatosis type 1, Thalamic tumors",

author = "Cross, {Kevin A.} and Afshin Salehi and Abdelbaki, {Mohamed S.} and Gutmann, {David H.} and Limbrick, {David D.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2022",

doi = "10.1007/s00381-022-05660-y",

language = "English",

journal = "Child's Nervous System",

issn = "0256-7040",

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TY - JOUR

T1 - MRI-guided laser interstitial thermal therapy for deep-seated gliomas in children with neurofibromatosis type 1

T2 - report of two cases

AU - Cross, Kevin A.

AU - Salehi, Afshin

AU - Abdelbaki, Mohamed S.

AU - Gutmann, David H.

AU - Limbrick, David D.

PY - 2022

Y1 - 2022

N2 - Purpose: Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors are refractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will have a positive impact on the outcome of these patients. Methods: We report on two illustrated cases of pediatric NF1- associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy (LITT). Results: Both tumors responded favorably to LITT. Conclusion: LITT should be considered as a treatment option for chemoresistant deep-seated NF1-associated low-grade gliomas.

AB - Purpose: Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors are refractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will have a positive impact on the outcome of these patients. Methods: We report on two illustrated cases of pediatric NF1- associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy (LITT). Results: Both tumors responded favorably to LITT. Conclusion: LITT should be considered as a treatment option for chemoresistant deep-seated NF1-associated low-grade gliomas.

KW - Deep-seated gliomas

KW - Laser interstitial thermal therapy

KW - Neurofibromatosis type 1

KW - Thalamic tumors

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DO - 10.1007/s00381-022-05660-y

M3 - Article

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AN - SCOPUS:85138049003

SN - 0256-7040

JO - Child's Nervous System

JF - Child's Nervous System

ER -

MRI-guided laser interstitial thermal therapy for deep-seated gliomas in children with neurofibromatosis type 1: report of two cases

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