MR three-dimensional molecular imaging of intramural biomarkers with targeted nanoparticles.

Tillmann Cyrus, Dana R. Abendschein, Shelton D. Caruthers, Thomas D. Harris, Veronica Glattauer, Jerome A. Werkmeister, John A.M. Ramshaw, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


In this study, porcine carotid arteries were subjected to balloon overstretch injury followed by local delivery of paramagnetic nanoparticles targeted to alphavbeta3-integrin expressed by smooth muscle cells or collagen III within the extracellular matrix. Carotid T1-weighted angiography and vascular imaging was performed at 1.5T. While MR angiograms were indistinguishable between control and targeted vessel segments, alphavbeta3-integrin-and collagen Ill-targeted nanoparticles spatially delineated patterns and volumes of stretch injury. In conclusion, MR molecular imaging with alphavbeta3-integrin or collagen Ill-targeted nanoparticles enables the non-invasive, three-dimensional characterization of arterial pathology unanticipated from routine angiography.

Original languageEnglish
Pages (from-to)535-541
Number of pages7
JournalJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Issue number3
StatePublished - 2006


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