TY - JOUR
T1 - MR three-dimensional molecular imaging of intramural biomarkers with targeted nanoparticles.
AU - Cyrus, Tillmann
AU - Abendschein, Dana R.
AU - Caruthers, Shelton D.
AU - Harris, Thomas D.
AU - Glattauer, Veronica
AU - Werkmeister, Jerome A.
AU - Ramshaw, John A.M.
AU - Wickline, Samuel A.
AU - Lanza, Gregory M.
PY - 2006
Y1 - 2006
N2 - In this study, porcine carotid arteries were subjected to balloon overstretch injury followed by local delivery of paramagnetic nanoparticles targeted to alphavbeta3-integrin expressed by smooth muscle cells or collagen III within the extracellular matrix. Carotid T1-weighted angiography and vascular imaging was performed at 1.5T. While MR angiograms were indistinguishable between control and targeted vessel segments, alphavbeta3-integrin-and collagen Ill-targeted nanoparticles spatially delineated patterns and volumes of stretch injury. In conclusion, MR molecular imaging with alphavbeta3-integrin or collagen Ill-targeted nanoparticles enables the non-invasive, three-dimensional characterization of arterial pathology unanticipated from routine angiography.
AB - In this study, porcine carotid arteries were subjected to balloon overstretch injury followed by local delivery of paramagnetic nanoparticles targeted to alphavbeta3-integrin expressed by smooth muscle cells or collagen III within the extracellular matrix. Carotid T1-weighted angiography and vascular imaging was performed at 1.5T. While MR angiograms were indistinguishable between control and targeted vessel segments, alphavbeta3-integrin-and collagen Ill-targeted nanoparticles spatially delineated patterns and volumes of stretch injury. In conclusion, MR molecular imaging with alphavbeta3-integrin or collagen Ill-targeted nanoparticles enables the non-invasive, three-dimensional characterization of arterial pathology unanticipated from routine angiography.
UR - http://www.scopus.com/inward/record.url?scp=33745889945&partnerID=8YFLogxK
U2 - 10.1080/10976640600580296
DO - 10.1080/10976640600580296
M3 - Article
C2 - 16755843
AN - SCOPUS:33745889945
SN - 1097-6647
VL - 8
SP - 535
EP - 541
JO - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
JF - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
IS - 3
ER -